HPA023887

Anti-FYN antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• Sinônimo(s): Anti-Proto-oncogene tyrosine-protein kinase Fyn, Anti-Protooncogene Syn, Anti-SLK, Anti-p59-Fyn
• Número MDL: MFCD01633360
• Código UNSPSC: 12352203
• Número do Atlas de Proteínas Humanas: HPA023887
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• linha de produto: Prestige Antibodies^® Powered by Atlas Antibodies
• Formulário: buffered aqueous glycerol solution
• reatividade de espécies: mouse, human, rat
• validação aprimorada: RNAi knockdown; Learn more about Antibody Enhanced Validation
• técnica(s): immunoblotting: 0.04-0.4 μg/mL; immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:50-1:200
• sequência de imunogênio: SFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIR
• nº de adesão UniProt: P06241
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... FYN(2534)

Descrição

Descrição geral

FYN (proto-oncogene, Src family tyrosine kinase) is located in human chromosome 6q21.

Fyn is a non-receptor type tyrosine kinase also called as tau kinase, which belongs to the Src family. It has two isoforms, FynB and FynT, expressed in brain and T-lymphocytes, respectively. The Fyn protein consist of Src homology domain 2 (SH2) and Src homology domain 3 (SH3) at its amino terminal ends.

Imunogênio

FYN proto-oncogene, Src family tyrosine kinase

Aplicação

Anti-FYN antibody has been used in western blotting and sodium dodecyl sulphate-polyacrylamide gel electrophoresis.

Anti-FYN antibody produced in rabbit has been used for Western blotting. All Prestige Antibodies^®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Ações bioquímicas/fisiológicas

FynT, an isoform of tyrosine-protein kinase Fyn, regulates neurofibrillary degeneration and reactive astrogliosis in Alzheimer′s disease (AD). The tyrosine kinase Fyn plays a vital role in acute transplant rejection, by phosphorylating tyrosine residues on key targets that take part in early T-cell signal transduction, which is a crucial process for acute transplant rejection. p59fyn (T) controls OKT3 promoted calcium ion transport in Jurkat T cells . Fyn facilitates the phosphorylation of Vav, a guanine nucleotide exchange factor for Rho-like small GTPases, and plays a crucial role in TCR-mediated actin polymerization. The Fyn protein associates with large myelin-associated glycoprotein (MAG) and plays a major role in myelinogenesis.

Características e benefícios

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Ligação

Corresponding Antigen APREST78892

forma física

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Informações legais

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable