H9523

Serotonin hydrochloride

≥98%, powder, neurotransmitter

• Sinônimo(s): 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride
• Fórmula empírica (Notação de Hill): C₁₀H₁₂N₂O · HCl
• Número CAS: 153-98-0
• Peso molecular: 212.68
• Beilstein: 3570963
• Número MDL: MFCD00012686
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278124
• NACRES: NA.77

Propriedades

• product name: Serotonin hydrochloride, powder
• Ensaio: ≥98%
• Nível de qualidade: 200
• forma: powder
• cor: white to off-white
• pf: 149-154 °C (lit.)
• solubilidade: H₂O: 17 mg/mL; 0.1 M HCl: 22 mg/mL; ethanol: 5.3 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl[H].NCCc1c[nH]c2ccc(O)cc12
• InChI: 1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
• chave InChI: MDIGAZPGKJFIAH-UHFFFAOYSA-N
• Informações sobre genes: human ... HTR3A(3359)

Descrição

Descrição geral

Serotonin is a ubiquitous molecule found in all animals. It shows diverse effects in the central and peripheral nervous system (CAN/PNS). Serotonin acts as a hormone and as a mitogen. It is produced in the axon terminal present in the brain. Action potential induces the release of serotonin that diffuses across the synapse to turn on the post-synaptic receptors. Serotonin plays a crucialrole in development, respiration, thermoregulation, endocrine, cardiovascular, and gastrointestinal functions. It also plays a role in sensory perceptional behaviors such as the sleep-wake cycle, sex, mood, memory, aggression, pain sensitivity, learning, and cognition. Serotonin impacts several psychiatric disorders such as schizophrenia, anorexia nervosa, depression, and a range of anxiety disorders such as obsessive-compulsive disorder, panic attacks, and social phobia. Variations in serotonin levels are associated withimpulse-related disorders or personalities like substance abuse, gambling, attention deficit disorder, obsessive-control, and aggression.

Aplicação

Serotonin hydrochloride hasbeen used: to study the mechanisms of 5-hydroxytryptamine receptor antagonistsregulate fibrosis in liver spheroids, to study its effects on theextracellular-related-kinase (ERK) phosphorylation in human embryonic kidneycells, in transwell assay, wound healing assay and tumor allograft assay incolon carcinoma cell line

Ações bioquímicas/fisiológicas

Neurotransmitter.

Características e benefícios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparo

Solutions should be freshly prepared.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H301,H361
• Declarações de precaução: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral - Repr. 2
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves