H2042
Histone H2A human
Sinônimo(s):
Histone, Human
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About This Item
Produtos recomendados
fonte biológica
human
Nível de qualidade
recombinante
expressed in E. coli
Formulário
liquid
concentração
1 mg/mL
nº de adesão UniProt
aplicação(ões)
cell analysis
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... H2AC20(8338)
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Descrição geral
Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA to form nucleosomes. A nucleosome comprises an octameric core histone made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B. The 147 DNA base pairs are wrapped around the histone complex. H2A consists of a C-terminal tail extending out of the nucleosome core particle.
Aplicação
Histone H2A human has been used as a neutrophil extracellular trap (NET) to study its effects on the membrane integrity and viability of macrophages (MFS) and dendritic cells (DCS). It has also been used in far-western blot analysis for protein identification.
Ações bioquímicas/fisiológicas
Histones modulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. N and C terminal tails undergo post-translational modifications (PTMs) altering DNA wrapping and chromatin regulation.
forma física
Supplied in 20 mM Na3PO4, pH 7.0, 0.3 M NaCl and 1 mM EDTA
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Carc. 1B
Código de classe de armazenamento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Khoa N Pham et al.
The journal of physical chemistry. B, 125(19), 4977-4986 (2021-05-12)
Histones are highly basic chromatin proteins that tightly package and order eukaryotic DNA into nucleosomes. While the atomic structure of the nucleosomes has been determined, the three-dimensional structure of DNA-free histones remains unresolved. Here, we combine tandem nonlinear and linear
Apurva Bhardwaj et al.
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Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is an essential protein that regulates cellular processes such as cell proliferation, apoptosis, and differentiation. It is known to bind with several proteins to carry out various cellular functions. In this study, we
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SpringerPlus, 4, 161-161 (2015-04-18)
Neutrophils are one the earliest, crucial innate defenses against innumerable pathogens. Their main microbicidal activities include phagocytosis and degranulation, with many pharmacologically active molecules contributing to inflammation. Recently, a novel antimicrobial mechanism was discovered; the Neutrophil Extracelullar Traps (NETs) formed
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