H0417

Heparin Cofactor II from human plasma

aqueous glycerol solution, ≥90% (SDS-PAGE)

• Sinônimo(s): HCF2, HCII, SERPIND1
• Número CAS: 81604-65-1
• Número MDL: MFCD00285907
• Código UNSPSC: 12352202
• NACRES: NA.61

Propriedades

• fonte biológica: human plasma
• Nível de qualidade: 200
• Ensaio: ≥90% (SDS-PAGE)
• Formulário: aqueous glycerol solution
• peso molecular: ~66 kDa; ~66 kDa
• nº de adesão NCBI: NP_000176
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... SERPIND1(3053)

Descrição

Ações bioquímicas/fisiológicas

Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.

Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.

Definição da unidade

HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.

forma física

50% aqueous glycerol solution (vol/vol)

Exoneração de responsabilidade

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable