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G8146

Sigma-Aldrich

Disialoganglioside GD1b from bovine brain

~95%, lyophilized powder

Sinônimo(s):

Ganglioside GD1b, disialo

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About This Item

Número CAS:
19553-76-5
Número MDL:
MFCD00466941
Código UNSPSC:
12352200
NACRES:
NA.77

Ensaio

~95%

Nível de qualidade

200

Formulário

lyophilized powder

temperatura de armazenamento

−20°C

InChI

1S/C80H144N4O37/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-54(96)83-36-49(44(91)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)111-74-65(104)63(102)67(52(40-88)114-74)116-76-66(105)72(68(53(41-89)115-76)117-73-57(84-43(3)90)71(61(100)51(39-87)112-73)118-75-64(103)62(101)60(99)50(38-86)113-75)121-80(78(108)109)35-46(93)56(82)70(120-80)59(98)48(95)42-110-79(77(106)107)34-45(92)55(81)69(119-79)58(97)47(94)37-85/h30,32,44-53,55-76,85-89,91-95,97-105H,4-29,31,33-42,81-82H2,1-3H3,(H,83,96)(H,84,90)(H,106,107)(H,108,109)/b32-30+/t44?,45-,46+,47?,48?,49?,50+,51+,52-,53+,55+,56-,57+,58?,59?,60-,61-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71+,72+,73-,74-,75-,76-,79-,80-/m1/s1

chave InChI

AIUBMTQAHKTQMI-MPGPKOMUSA-N

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Categorias relacionadas

Amino Acid Sequence

Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal

Descrição geral

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Ações bioquímicas/fisiológicas

May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
039M4041V
14180704
058M4072V
14180221
117M4156V

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Galactocerebrosides from bovine brain ≥97% (TLC)

Sigma-Aldrich

C4905

Galactocerebrosides from bovine brain

Monosialoganglioside GM1 from bovine brain lyophilized powder, BioXtra, γ-irradiated, ≥95% (TLC)

Sigma-Aldrich

G9652

Monosialoganglioside GM1 from bovine brain

Ganglioside GM1 (Ovine Brain) Avanti Research™ - A Croda Brand

Avanti

860065P

Ganglioside GM1 (Ovine Brain)

Ricardo D Lardone et al.
Journal of neurology, neurosurgery, and psychiatry, 81(6), 629-633 (2009-12-08)
Clinical severity of Guillain-Barré syndrome (GBS) is highly variable, but the immunopathological reason is unknown. The study was designed to show which antibody parameters are associated with disease severity in GBS patients with serum anti-GM1 IgG antibodies. Thirty-four GBS patients
Vivian Marino Mazucato et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 59(4), 428-440 (2011-03-18)
The role of the mast cell-specific gangliosides in the modulation of the endocytic pathway of FcεRI was investigated in RBL-2H3 cells and in the ganglioside-deficient cell lines, E5 and D1. MAb BC4, which binds to the α subunit of FcεRI
[Case report; A case of anti-GD1b antibody positive pure motor form Guillain-Barré syndrome with good response to combined IVIg and steroid therapy].
Takeshi Fujimoto et al.
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 100(6), 1651-1653 (2011-07-21)
Ana L Moyano et al.
Glycobiology, 22(12), 1768-1774 (2012-07-31)
Immunization of rabbits with bovine brain gangliosides induced an experimental neuropathy, with clinical signs resembling Guillain-Barré syndrome. All the immunized animals developed immunoglobulin G immunoreactivity to GM1 ganglioside. In a few (4 of 27) animals, an additional anti-ganglioside antibody population
Keiichiro Susuki et al.
Experimental neurology, 233(1), 534-542 (2011-12-20)
Autoantibodies against gangliosides GM1 or GD1a are associated with acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), whereas antibodies to GD1b ganglioside are detected in acute sensory ataxic neuropathy (ASAN). These neuropathies have been proposed to be
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