G8044
Anti-phospho-GATA4 (pSer105) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
conjugado:
unconjugated
application:
WB
clone:
polyclonal
reatividade de espécies:
mouse
citations:
2
técnica(s):
western blot: 1:500
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
peso molecular
antigen 46 kDa
reatividade de espécies
mouse
embalagem
pkg of (1 vl = 100ul)
técnica(s)
western blot: 1:500
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... GATA4(2626)
mouse ... Gata4(14463)
rat ... Gata4(54254)
Categorias relacionadas
Imunogênio
Anti-phospho-GATA4 (pSer105) antibody produced in rabbit is suitable for western blotting at working dilution 1:500.
synthetic phosphopeptide derived from the region of GATA-4 that contains serine 105.
Ações bioquímicas/fisiológicas
GATA-4 has a molar mass of 46kDa and belongs to the GATA family of zinc finger-containing transcription factors. It is involved in the development of cardiac hypertrophy and remodeling. It plays a crucial role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. Upon agonist stimulation via MEK1-ERK1/2, and weakly via JNK or p38 MAPKs, Ser105 of GATA-4 is phosphorylated. Phosphorylation of GATA-4 by hepatocyte growth factor facilitates cell survival in cardiac muscle cells via MEK/ERK-dependent signaling pathway.
forma física
Solution in Dulbecco′s PBS, pH 7.3 with 1 mg/mL BSA and 0.05% Sodium Azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
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Kazumi Kitta et al.
The Journal of biological chemistry, 278(7), 4705-4712 (2002-12-07)
Hepatocyte growth factor (HGF) is released in response to myocardial infarction and may play a role in regulating cardiac remodeling. Recently, HGF was found to inhibit the apoptosis of cardiac muscle cells. Because GATA-4 can induce cell survival, the effects
Q Liang et al.
Molecular and cellular biology, 21(21), 7460-7469 (2001-10-05)
The zinc finger-containing transcription factor GATA4 has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regulator of inducible gene expression in response to hypertrophic stimulation. Here we demonstrate that GATA4 is itself regulated by
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