G5640

Globulins Cohn fraction II, III from goat

• Sinônimo(s): Vitamin D binding protein
• Número CAS: 68476-36-8
• Número CE: 270-678-2
• Número MDL: MFCD00164084
• Código UNSPSC: 12352202
• NACRES: NA.61

Propriedades

• fonte biológica: goat
• Nível de qualidade: 300
• Ensaio: 73-90% protein basis (biuret)
• Formulário: lyophilized powder
• composição: Protein, 73-90% biuret
• solubilidade: H₂O: soluble 25 mg/mL
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

Vitamin D binding protein (DBP) is a polymorphic protein that specifically binds to vitamin D and its metabolites. This protein belongs to the albuminoid family and is highly conserved among vertebrates. The gene encoding DBP is mapped to human chromosome 4q11-q13. It is predominantly produced in the liver and is also expressed in the kidney, endocrine pancreatic cells, fat cells, and testis.

Aplicação

Globulins were used in Biotin/avidin formulations.

Ações bioquímicas/fisiológicas

Vitamin D binding protein (DBP) specifically binds and transports vitamin D and its metabolites with high affinity. It promotes fibrillar actin clearance by binding to actin monomers. DBP also binds to unsaturated fatty acids, megalin-cubilin receptor complex, the membrane of leukocytes, and the activation of the complement C5 system. The levels of DBP indicate the free concentration of all vitamin D metabolites. Decreased levels of serum DBP are observed in liver diseases, nephrotic syndrome, malnutrition, severe acute trauma, or disease.

Outras notas

Primarily γ-globulins

forma física

Lyophilized powder containing NaCl

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable