G1670
Anti-Glutamate Receptor 4, Metabotropic antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinônimo(s):
Anti-mGluR4
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About This Item
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
reatividade de espécies
human
disponibilidade
not available in Japan
técnica(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3 μg/mL using human neurons, cortex
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... GRM4(2914)
mouse ... Grm4(268934)
rat ... Grm4(24417)
Imunogênio
synthetic peptide corresponding to the N-terminal extracellular domain of human metabotropic glutamate receptor 4, conjugated to KLH. The immunizing peptide has 100% homology with the rat gene and 89% homology with the mouse gene.
Aplicação
Anti-Glutamate Receptor 4, Metabotropic antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 3μg/mL using human neurons, cortex.
Ações bioquímicas/fisiológicas
Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of group I appear to have a neuroprotective effect.
forma física
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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W Spooren et al.
Behavioural pharmacology, 14(4), 257-277 (2003-07-03)
Following the molecular cloning in the early 1990s of the metabotropic glutamate receptors (mGlu1-8), research that focused on the physiology, pharmacology and function of these receptors revealed their potential role in CNS disorders. Numerous psychiatric and neurological dis-orders are indeed
Domenico E Pellegrini-Giampietro
Trends in pharmacological sciences, 24(9), 461-470 (2003-09-12)
Metabotropic glutamate receptors of the mGlu(1) and mGlu(5) subtypes exhibit a high degree of sequence homology and are both coupled to phospholipase C and intracellular Ca(2+) mobilization. However, functional differences have been detected for these receptor subtypes when they are
Metabotropic glutamate receptors in the cerebellum with a focus on their function in Purkinje cells.
Thomas Knöpfel et al.
Cerebellum (London, England), 1(1), 19-26 (2003-07-26)
Metabotropic glutamate receptors (mGluRs) are a family of proteins that have seven transmembrane segments and that couple to G proteins. They differ from ionotropic glutamate receptors in that they do not form ion channels but instead affect intracellular chemical messenger
J P Pin et al.
Neuropharmacology, 34(1), 1-26 (1995-01-01)
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to
Peter J Flor et al.
Advances in experimental medicine and biology, 513, 197-223 (2003-02-11)
Metabotropic glutamate receptors form a family of currently eight subtypes (mGluR1-8), subdivided into three groups (I-III). Activation of group-II (mGluR2 and -3) or group-III metabotropic glutamate receptors (mGluR4, -6, -7 and -8) has been established to be neuroprotective in vitro
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