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G1276

Sigma-Aldrich

Gastrin I rat

≥97% (HPLC)

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About This Item

Fórmula empírica (Notação de Hill):
C94H128N22O31S2
Número CAS:
81123-06-0
Peso molecular:
2126.28
Número MDL:
MFCD00076501
Código UNSPSC:
51111800
ID de substância PubChem:
24895057
NACRES:
NA.32

fonte biológica

rat

Nível de qualidade

200

Ensaio

≥97% (HPLC)

nº de adesão UniProt

P04563

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C(Cc3ccc(O)cc3)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCSC)NC(=O)C4CCCN4C(=O)C5CCCN5C(=O)C(CCCNC(N)=N)NC(=O)C6CCC(=O)N6)C(=O)NC(CC(O)=O)C(=O)NC(Cc7ccccc7)C(N)=O

InChI

1S/C94H128N22O31S2/c1-48(79(133)113-65(43-50-19-21-52(117)22-20-50)80(134)100-47-71(119)103-66(44-51-46-99-54-15-8-7-14-53(51)54)89(143)109-61(35-40-148-2)88(142)114-67(45-77(130)131)90(144)112-64(78(95)132)42-49-12-5-4-6-13-49)101-81(135)56(24-30-72(120)121)104-83(137)57(25-31-73(122)123)105-84(138)58(26-32-74(124)125)106-85(139)59(27-33-75(126)127)107-86(140)60(28-34-76(128)129)108-87(141)62(36-41-149-3)110-91(145)68-17-10-38-115(68)93(147)69-18-11-39-116(69)92(146)63(16-9-37-98-94(96)97)111-82(136)55-23-29-70(118)102-55/h4-8,12-15,19-22,46,48,55-69,99,117H,9-11,16-18,23-45,47H2,1-3H3,(H2,95,132)(H,100,134)(H,101,135)(H,102,118)(H,103,119)(H,104,137)(H,105,138)(H,106,139)(H,107,140)(H,108,141)(H,109,143)(H,110,145)(H,111,136)(H,112,144)(H,113,133)(H,114,142)(H,120,121)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H4,96,97,98)

chave InChI

FUTWNIPXZKAJHO-UHFFFAOYSA-N

Informações sobre genes

rat ... Gast(25320)

Amino Acid Sequence

Glp-Arg-Pro-Pro-Met-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

Descrição geral

Gastrin is a pyloric antral hormone, which is a small biologically active peptide thatis synthesized as a precursor. It is found to be produced in antral G cells.

Aplicação

Gastrin I has been used in a study for gastrin stimulation in rats to determine the expression of histidine decarboxylase and histamine metabolism in gastric oxyntic mucosa during conditions of hypergastrinemia and carcinoid tumor. It has also been used for preabsorption of anti-gastrin antibody prior to immunohistochemical assay in rats.

Ações bioquímicas/fisiológicas

Gastrin plays a crucial role in the maintenance of architecture and function of oxyntic mucosa of stomach, which is involved in the secretion of acid. It also triggers the secretion of acid into the gastric lumen. Continuous increased plasma levels of gastrin or hypergastrinemia, may be involved in gastrointestinal carcinogenesis, especially if it is accompanied with inflammation. The release of this peptide is suppressed during distention, which is a result of omatostatin and intrinsic cholinergic pathways. In rats, this peptide maintains gastric mucosal integrity through the up-regulation of cyclooxygenase-2 which is, in part, mediated by heparin-binding epidermal growth factor-like growth factor (HB-EGF).

Outras notas

Lyophilized from 0.1% TFA in H2O

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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L Kölby et al.
Endocrinology, 137(10), 4435-4442 (1996-10-01)
Histamine is an important stimulator of gastric acid secretion. In experimental animals, inhibition of acid secretion by long term histamine2 receptor blockade causes hypergastrinemia, proliferation of enterochromaffin-like (ECL) cells, and formation of histamine-producing gastric carcinoids. The aim of this study
Masato Komori et al.
American journal of physiology. Gastrointestinal and liver physiology, 283(6), G1368-G1378 (2002-10-22)
Gastrin, PGs, and growth factors have important roles in maintaining gastrointestinal mucosal integrity. Cyclooxygenases (COX-1 and COX-2) are the key enzymes involved in PG synthesis. This study aimed to clarify the mechanisms of gastric mucosal protection by gastrin. Fasted rats
Rat gastrin's amino acid sequence determined from the nucleotide sequence of the mRNA.
M H Schaffer et al.
Peptides, 3(4), 693-696 (1982-07-01)
Christina Sæten Fjeldbo et al.
American journal of physiology. Gastrointestinal and liver physiology, 302(1), G21-G33 (2011-10-15)
We show that the gastric hormone gastrin induces the expression of the prosurvival secretory clusterin (sCLU) in rat adenocarcinoma cells. Clusterin mRNA was still upregulated in the presence of the protein synthesis inhibitor cycloheximide, although at a lower level. This
A Varro et al.
The Journal of biological chemistry, 265(35), 21476-21481 (1990-12-15)
Post-translational processing of the precursor for rat gastrin yields products that include peptides phosphorylated at Ser96, amidated at Phe92, and sulfated at Tyr87 or Tyr103. The phosphorylation site is immediately adjacent to the processing point that gives rise to the
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