G11100P

DMT-dG(ib) Pharmadite^®

• Sinônimo(s): DMT-dG(ib) Phosphoramidite, N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyguanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• Fórmula empírica (Notação de Hill): C₄₄H₅₄N₇O₈P
• Número CAS: 93183-15-4
• Peso molecular: 839.92
• Número MDL: MFCD00055147
• Código UNSPSC: 12352200
• ID de substância PubChem: 329799722

Propriedades

• fonte biológica: non-animal source (no BSE/TSE risk)
• Nível de qualidade: 300
• tipo: for DNA synthesis
• linha de produto: Proligo Reagents
• Ensaio: ≥99.5% (reversed phase HPLC); >99.5% (³¹P-NMR)
• forma: powder or granules
• técnica(s): oligo synthesis: suitable
• Impurezas: >= 170ppm, none detected (S/N <2.5); ≤0.1% P(III) 100-169ppm (³¹P-NMR); ≤0.1% single unspecified Imprity (reversed phase HPLC); ≤0.3% dG2 (reversed phase HPLC, DMT-dG(ib) cyanoethyl-H-posphonate); ≤0.3% dG3 (reversed phase HPLC, DMT-dG(ib) phosphoramidate); ≤0.3% dG4 (reversed phase HPLC, DMT-dG(ib)-diisopropylamino-H-phosphonate); ≤0.30 wt. % water content (Karl Fischer); ≤0.5% P(V) -25-99ppm (³¹P-NMR); ≤3.0 wt. % residual solvent content
• cor: white to off-white
• solubilidade: soluble, clear
• adequação: conforms to structure for H-NMR; conforms to structure for LC-MS
• perfil de nucleosídeo: base: deoxyguanosine; base protecting group: isobutyryl; 2' protecting group: none; 5' protecting group: DMT; deprotection: standard
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(NC(=O)C(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6
• InChI: 1S/C44H54N7O8P/c1-28(2)41(52)48-43-47-40-39(42(53)49-43)46-27-50(40)38-25-36(59-60(57-24-12-23-45)51(29(3)4)30(5)6)37(58-38)26-56-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H2,47,48,49,52,53)/t36-,37+,38+,60?/m0/s1
• chave InChI: FDRMKYVTIFSDPR-MMROLVBFSA-N

Descrição

Descrição geral

DMT-dG(ib) Pharmadite^® is a Pharmadite^® product line that represents a new class of standard protected DNA phosphoramidites designed with highly controlled impurity profiles and exceptional overall purity. Pharmadite phosphoramidites are characterized by their exceptional purity and well-defined impurity profile. In particular, they are essentially free from contaminants that interfere in coupling reactions, such as other nucleosidic or non-nucleosidic phosphoramidites (P(III)-contaminants). All remaining impurities in Pharmadite phosphopramidites, if present, are identified, characterized, and quantified. The impact of any such defined impurities on the synthesis of oligonucleotides is well understood and has been shown to be insignificant.

Informações legais

Pharmadite is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable