SAB4500329
Anti-CCR7 antibody produced in rabbit
affinity isolated antibody
Sinônimo(s):
C-C CKR-7, C-C chemokine receptor type 7, CC-CKR-7, CCR-7, MIP-3 β receptor
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About This Item
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
peso molecular
antigen 42 kDa
reatividade de espécies
human
concentração
~1 mg/mL
técnica(s)
ELISA: 1:40000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CCR7(1236)
Descrição geral
C-C motif chemokine receptor 7 (CCR7) also known as EBI1, is encoded by the gene mapped to human chromosome 17q12-q21.2. The encoded protein is a member of chemokine receptor family and is expressed mainly by B cells, T cells, and on activated mature dendritic cells (DCs).
CCR7 is a G protein-coupled seven-transmembrane domain receptor. It has two high-affinity ligands, secondary lymphoid chemokine (SLC) and EB11-ligand chemokine (ELC).
Imunogênio
The antiserum was produced against synthesized peptide derived from human CCR7.
Immunogen Range: 170-219
Immunogen Range: 170-219
Aplicação
Anti-CCR7 antibody produced in rabbit has been used for proximity ligation assay (PLA).
Anti-CCR7 antibody produced in rabbit has been used in immunofluorescence (1:50).
Ações bioquímicas/fisiológicas
C-C motif chemokine receptor 7 (CCR7) harmonizes the antigen-specific immune response by combining T cells, B cells, and dendritic cells (DCs), to form functional microenvironments in the secondary lymphoid organs. CCR7 controls trafficking of skin DC under both inflammatory and steady-state conditions. This protein is also involved in emigration pathway of mature DCs from the skin to regional lymph nodes in vivo. CCR7 oligomers function acts as a scaffolds to link distinct signaling pathways for cell migration. Interaction of CCR7 with its ligand, CCL21/6ckine is essential for preferential lymph node metastasis of gastric carcinoma.
CCR7 can stimulate the development of hepatocellular carcinoma (HCC). In human malignancies, CCR7 may act as an initiator of epithelial-mesenchymal transition (EMT).
Características e benefícios
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forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
Ohl L, et al.
Immunity, 21(2), 279-288 (2004)
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Forster R, et al.
Cell, 99(1), 23-33 (1999)
Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration.
Hauser MA, et al.
Immunity, 44(1), 59-72 (2016)
Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers.
Lamy PJ, et al.
Breast Cancer Research, 13(1) (2011)
Lingling Yang et al.
Experimental cell research, 371(1), 231-237 (2018-08-15)
The effects of Histone deacetylase (HDAC) inhibition on epithelial-mesenchymal transition (EMT) differs in various types of cancers. However, its function in hepatocellular carcinoma (HCC) is not well-explored. In this study, we investigated the effect of HDAC inhibition on EMT in
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