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F2177

Sigma-Aldrich

Follistatin 288 from mouse

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Sinônimo(s):

FS-288

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About This Item

Número MDL:
MFCD03456879
Código UNSPSC:
51111800
NACRES:
NA.32

fonte biológica

mouse

Nível de qualidade

100

recombinante

expressed in baculovirus infected Sf21 cells

Ensaio

>95% (SDS-PAGE)

forma

lyophilized powder

potência

0.04-0.4 mg per mL

peso molecular

calculated mol wt ~31 kDa

embalagem

pkg of 25 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

Impurezas

endotoxin, tested

nº de adesão UniProt

P47931

temperatura de armazenamento

−20°C

Informações sobre genes

mouse ... Fst(14313)

Descrição geral

FST (follistatin) is an activin-binding protein, and exists in two isoforms due to alternate splicing, FS288 and FS315. It is a glycoprotein with a single chain, and acts as an activin antagonist. It has a high level of expression in fetal membranes and placenta.

Ações bioquímicas/fisiológicas

FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders. The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells.
High affinity activin-binding protein that can act as an activin antagonist.

forma física

Recombinant Mouse Follistatin 288 is supplied as a approximately 25 μg of protein lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg of bovine serum albumin.

Nota de análise

The biological activity is measured by its ability to neutralize activin-induced erythroid differentiation on K562 cells.

Pictogramas

Corrosion
GHS05

Palavra indicadora

Danger

Frases de perigo

H315,H318

Declarações de precaução

P280 - P305 + P351 + P338 + P310

Classificações de perigo

Eye Dam. 1 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Rita Linko et al.
BMC infectious diseases, 14, 253-253 (2014-06-03)
Activin A and its binding protein follistatin (FS) are increased in inflammatory disorders and sepsis. Overexpression of activin A in the lung causes similar histopathological changes as acute respiratory distress syndrome (ARDS). ARDS and severe respiratory failure are complications of
Silvia Näf et al.
PloS one, 9(4), e92175-e92175 (2014-04-26)
The Activin A-Follistatin system has emerged as an important regulator of lipid and glucose metabolism with possible repercussions on fetal growth. To analyze circulating activin A, follistatin and follistatin-like-3 (FSTL3) levels and their relationship with glucose metabolism in pregnant women
S Dasgupta et al.
Journal of postgraduate medicine, 58(3), 190-193 (2012-10-02)
Out of a panel of 37 candidate genes tested for linkage with polycystic ovary syndrome (PCOS), the strongest evidence of linkage was reported in the follistatin (FST) gene region. Subsequently, a couple of studies outside India investigated the FST gene

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