F132

Fluoxetine hydrochloride

≥98% (TLC), solid, selective serotonin reuptake inhibitor 

• Sinônimo(s): Fluoxetine HCl, (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac^®
• Fórmula empírica (Notação de Hill): C₁₇H₁₈F₃NO · HCl
• Número CAS: 56296-78-7
• Peso molecular: 345.79
• Número CE: 260-101-2
• Número MDL: MFCD00214288
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278096
• NACRES: NA.77

Propriedades

• Nome do produto: Fluoxetine hydrochloride, solid
• Formulário: solid
• cor: white
• solubilidade: H₂O: 4 mg/mL; DMSO: >5 mg/mL
• originador: Eli Lilly
• cadeia de caracteres SMILES: CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl
• InChI: 1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H
• chave InChI: GIYXAJPCNFJEHY-UHFFFAOYSA-N
• Informações sobre genes: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Descrição

Descrição geral

Fluoxetine hydrochloride is a psychotropic agent and one of the initial members of the anti-depressant class of drugs known as selective serotonin-reuptake inhibitors (SSRIs). It is the active ingredient of Prozac^®.

Aplicação

Fluoxetine hydrochloride has been used to study its effect on the binding ability of the radiopharmaceutical 123I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (^[123I]ADAM) to SERT (serotonin transporters) in mice. It has also been used for the chronic treatment of light deprived animals.It has also been used as a serotonin reuptake inhibitor to study its effects on acute stress in fish.

Ações bioquímicas/fisiológicas

Fluoxetine hydrochloride works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.

Selective serotonin reuptake inhibitor; antidepressant.

Características e benefícios

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações legais

Sold under license from Eli Lilly and Company.

Prozac is a registered trademark of Eli Lilly and Co.

Informações de segurança

• Pictogramas: GHS08,GHS05,GHS07,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H302,H318,H336,H373,H410
• Declarações de precaução: P260 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P314
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3
• Órgãos-alvo: Central nervous system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves