F0931
Factor Va human
≥1500 units/mg protein
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About This Item
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Descrição geral
Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma.
Factor Va is the activated form of factor V and the cofactor of Xa. It is a component of the prothrombinase complex.
Ações bioquímicas/fisiológicas
Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. It has been used in studies of coagulopathic bleeding which occurs following injury and is a leading cause of hospital deaths.
Factor Va serves as a receptor and positive effector of factor Xa. Hence it can efficiently help in the conversion of prothrombin to thrombin.
Ligação
View this factors role in the Coagulation Cascade
Definição da unidade
One unit is equivalent to the Factor V activity in 1.0 mL of normal human plasma at pH 7.4 at 37 °C.
forma física
Aqueous solution containing 50% (v/v) glycerol and 5mM CaCl2
Exoneração de responsabilidade
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
The factor V activation paradox
Orfeo T, et al.
The Journal of Biological Chemistry, 279(19), 19580-19591 (2004)
Less Common Congenital Disorders of Hemostasis
Consultative Hemostasis and Thrombosis, 60-78 (2013)
Sandro B Rizoli et al.
The Journal of trauma, 71(5 Suppl 1), S427-S434 (2011-12-17)
Coagulopathic bleeding is a leading cause of in-hospital death after injury. A recently proposed transfusion strategy calls for early and aggressive frozen plasma transfusion to bleeding trauma patients, thus addressing trauma-associated coagulopathy (TAC) by transfusing clotting factors (CFs). This strategy
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