E7881

Emodin

from Frangula bark, ≥90% (HPLC), casein Kinase 2 (CK2) inhibitor

• Sinônimo(s): 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione, 1,3,8-Tri­hydroxy-6-methyl­anthra­quinone, 6-Methyl-1,3,8-tri­hydroxy­anthra­quinone, Archin, Emodol, Frangula-emodin, Frangulic acid, Rheum emodin
• Fórmula empírica (Notação de Hill): C₁₅H₁₀O₅
• Número CAS: 518-82-1
• Peso molecular: 270.24
• Beilstein: 1888141
• Número CE: 208-258-8
• Número MDL: MFCD00001207
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278164
• NACRES: NA.77

Propriedades

• Nome do produto: Emodin, from Frangula bark, ≥90% (HPLC)
• fonte biológica: Frangula bark
• Ensaio: ≥90% (HPLC)
• solubilidade: DMSO: soluble; aqueous base: soluble; ethanol: soluble
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
• InChI: 1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
• chave InChI: RHMXXJGYXNZAPX-UHFFFAOYSA-N
• Informações sobre genes: human ... CSNK2A1(1457) , CSNK2B(1460) , ELA2(1991) , NFKB1(4790) , NKAP(79576) , NKRF(55922)

Descrição

Descrição geral

Emodin is an anthraquinone derivative, extracted from rhubarb (Rheum palmatum). It has antibacterial, anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. Emodin exhibits cytotoxic effects, apoptosis and stimulates the expression of hypoxia-inducible factor 1α, glutathione S-transferase P and N-acetyltransferase. It prevents the growth of prostate cancer cells. Emodin is used to treat constipation and hemorrhoid. It displays immunosuppressive and anti-diabetic effects.

Aplicação

Emodin has been used:

• to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis
• as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method
• to inhibit Tau aggregation
• for direct binding assay

Ações bioquímicas/fisiológicas

Inhibitor of NF-κB activation and adhesion molecule expression. Casein Kinase 2 (CK2) inhibitor.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves