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E7280

Sigma-Aldrich

Elafin

recombinant, expressed in Saccharomyces cerevisiae, powder, >90% (by MS, HPLC and SDS-PAGE),

Sinônimo(s):

Elastase-specific inhibitor, skin-derived antileukoprotease

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About This Item

Número MDL:
MFCD00146824
Código UNSPSC:
12352202
NACRES:
NA.77

product name

Elafin human, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae

recombinante

expressed in Saccharomyces cerevisiae

Nível de qualidade

200

Ensaio

>90% (by MS, HPLC and SDS-PAGE)

forma

powder

potência

1.7 x 10-10 M Ki (human leukocyte elastase)
4.2 x 10-10 M Ki (human proteinase 3)

peso molecular

~6 kDa

nº de adesão UniProt

P19957

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria

Modo de ação

enzyme | inhibits

Condições de expedição

ambient

temperatura de armazenamento

−20°C

Informações sobre genes

human ... PI3(5266)

Descrição geral

Chemical structure: peptide

Ações bioquímicas/fisiológicas

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.
Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Viraj J Jasinghe et al.
BioResearch open access, 2(2), 128-137 (2013-04-18)
Trappin-2/elafin is a novel innate immune factor that belongs to the serine protease inhibitor family and has known antibacterial, antifungal, and antiviral properties. In this study, we further investigated the anti-HIV activity of elafin using different cellular models and both
Lingling Shu et al.
Clinical science (London, England : 1979), 134(13), 1679-1696 (2020-07-08)
Type 1 diabetes is an autoimmune disease resulted from self-destruction of insulin-producing pancreatic β cells. However, the pathological pathways that trigger the autoimmune destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with
T Dau et al.
Scientific reports, 6, 35413-35413 (2016-10-16)
High abundance proteins like protease inhibitors of plasma display a multitude of interactions in natural environments. Quantitative analysis of such interactions in vivo is essential to study diseases, but have not been forthcoming, as most methods cannot be directly applied
Jiani Wang et al.
Scientific reports, 10(1), 12785-12785 (2020-08-01)
Elafin is an antimicrobial and anti-inflammatory protein. We hypothesize that elafin expression correlates with diabetes. Among non-diabetic and prediabetic groups, men have significantly higher serum elafin levels than women. Men with type 2 diabetes mellitus (T2DM) have significantly lower serum
J A Caruso et al.
Oncogene, 34(27), 3556-3567 (2014-09-10)
The serine protease inhibitor, elafin, is a critical component of the epithelial barrier against neutrophil elastase (NE). Elafin is downregulated in the majority of breast cancer cell lines compared with normal human mammary epithelial cells (HMECs). Here, we evaluated the
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Artigos

Elastase

Enzyme Explorer Product Application Index for Elastase. Leukocyte elastase is a 29KDa serine endoprotease of the Proteinase S1 Family. It exists as a single 238 amino acid-peptide chain with four disulfide bonds.

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