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E006

Sigma-Aldrich

β-Carboline-3-carboxylic acid N-methylamide

Sinônimo(s):

β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide

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About This Item

Fórmula empírica (Notação de Hill):
C13H11N3O
Número CAS:
78538-74-6
Peso molecular:
225.25
Número MDL:
MFCD00055075
Código UNSPSC:
12352106
ID de substância PubChem:
24278181
NACRES:
NA.77

forma

solid

Nível de qualidade

100

cor

light tan

solubilidade

DMSO: >10 mg/mL
H2O: insoluble

cadeia de caracteres SMILES

CNC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)

chave InChI

QMCOPDWHWYSJSA-UHFFFAOYSA-N

Informações sobre genes

human ... BZRAP1(9256)

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Ações bioquímicas/fisiológicas

Benzodiazepine inverse receptor agonist; potent anxiogenic agent.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Atenção

Solutions may be stored for several days at 4 °C.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Andrew R Delamater et al.
Journal of experimental psychology. Animal behavior processes, 35(2), 224-237 (2009-04-15)
Previous research has reported a role for the neurotransmitter gamma-aminobutyric acid (GABA) in the extinction and renewal of conditioned fear. Here, the authors examine whether GABA is involved in the acquisition, extinction, renewal, spontaneous recovery, and latent inhibition of appetitive
Kwok Ho C Choy et al.
Psychopharmacology, 221(4), 649-657 (2011-12-24)
Vigilant scanning of the environment is a major risk assessment activity in many species. However, due to difficulties in its manual scoring, scanning has rarely been quantified in laboratory rodent studies. We developed a novel method for automated measurement of
Sarah I Martire et al.
Behavioural brain research, 209(1), 131-136 (2010-02-02)
Three experiments used intake, clusters, and licks per cluster to study the effects of the GABA inverse agonist, FG 7142, on sensory-specific satiety in rats. In Experiment 1, rats were offered one of two palatable solutions and 30min later tested
Joshua B B Garfield et al.
Behavioral neuroscience, 123(1), 75-85 (2009-01-28)
Six experiments studied the role of GABA-sub(A) receptor activation in expression of overexpectation of Pavlovian fear conditioning. After separate pairings of CSA and CSB with shock in Stage I, rats received pairings of the compound AB with shock in Stage
Hongrun Yu et al.
PloS one, 7(8), e42684-e42684 (2012-08-29)
Post-traumatic stress disorder (PTSD) is an anxiety disorder that not only affects mental health, but may also affect bone health. However, there have been no studies to examine the direct relationship between PTSD and bone. We employed electric shocks in
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