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D9175

Sigma-Aldrich

Dantrolene sodium salt

Sinônimo(s):

1-[(5-­(p-Nitro­phenyl)­fur­furyl­idene)­amino]­hydan­toin sodium salt

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About This Item

Fórmula empírica (Notação de Hill):
C14H9N4NaO5
Número CAS:
14663-23-1
Peso molecular:
336.23
Número MDL:
MFCD00079130
Código UNSPSC:
12352200
ID de substância PubChem:
24278823
NACRES:
NA.77

Formulário

solid

Nível de qualidade

200

originador

JHP Pharmaceuticals

cadeia de caracteres SMILES

[Na+].[H]\C(=N/N1CC(=O)N=C1[O-])c2ccc(o2)-c3ccc(cc3)[N+]([O-])=O

InChI

1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

chave InChI

KSRLIXGNPXAZHD-HAZZGOGXSA-M

Informações sobre genes

human ... RYR1(6261) , RYR3(6263)

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Ações bioquímicas/fisiológicas

Inhibitor of Ca2+ release from sarcoplasmic reticulum; muscle relaxant.

Características e benefícios

This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by JHP Pharmaceuticals. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
059M4018V
078M4062V
048M4012V
048M4064V
087M4029V

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Eshwar Reddy Tammineni et al.
Virology, 553, 81-93 (2020-11-30)
Dengue virus (DENV) infection elevates intracellular Ca2+ concentration ([Ca2+]i), but it is unknown whether Ca2+ and calmodulin (CaM) are involved in DENV infection. We conducted immunofluorescence and western blot experiments and measured [Ca2+]i examining the effects of DENV infection and
Beth A McNally et al.
Frontiers in physiology, 12, 737291-737291 (2021-10-16)
Daily regulation of Ca2+ - and voltage-activated BK K+ channel activity is required for action potential rhythmicity in the suprachiasmatic nucleus (SCN) of the hypothalamus, the brain's circadian clock. In SCN neurons, BK activation is dependent upon multiple types of
G Haskó et al.
British journal of pharmacology, 124(6), 1099-1106 (1998-08-28)
1. Intracellular calcium has been suggested to be an important mediator of the cellular response in endotoxaemia and shock. Dantrolene is an agent that interferes with intracellular calcium fluxes resulting in a decreased availability of calcium in the cytoplasm. Here
Mohammed Ali Azam et al.
Heart rhythm O2, 2(6Part B), 733-741 (2022-01-07)
Doxorubicin (Dox) is a potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. Intracellular calcium dysregulation has been reported to be involved in doxorubicin-induced cardiomyopathy (DICM). The cardioprotective role of RyR stabilizer dantrolene (Dan) on the calcium dynamics
Jiao Liu et al.
Frontiers in pharmacology, 13, 882198-882198 (2022-05-07)
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to heart failure and death, for which there is no effective treatment. Rhynchophylline (Rhy) is the main effective component of the Chinese herbal medicine Uncaria rhynchophylla, which mainly
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