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D9050

Sigma-Aldrich

N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid

≥93% (TLC)

Sinônimo(s):

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid

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About This Item

Fórmula empírica (Notação de Hill):
C11H17NO8
Número CAS:
24967-27-9
Peso molecular:
291.25
Beilstein:
8722455
Número CE:
246-550-7
Número MDL:
MFCD00135810
Código UNSPSC:
12352201
ID de substância PubChem:
24894248
NACRES:
NA.25

fonte biológica

synthetic (organic)

Nível de qualidade

300

Ensaio

≥93% (TLC)

Formulário

powder

atividade óptica

[α]20/D 40.8 to 51.0 °, c = 0.66% (w/v) in water

cor

white

solubilidade

H2O: soluble 50 mg/mL, clear, colorless

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O

InChI

1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1

chave InChI

JINJZWSZQKHCIP-UFGQHTETSA-N

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Aplicação

N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid (NADNA), a specific endogenous neuraminidase (NEU) inhibitor, may be used to study the roles of endogenous neuraminidase in the development and function of neural processes and pathways as well as other processes that depend upon sialylation-desialylation cycles.

Ações bioquímicas/fisiológicas

Inhibitor of bacterial, viral and animal neuraminidase (sialidase).

Outras notas

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
SLCF5591
SLBZ7241
SLBW5482
SLBJ4759V
SLBH1667V

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Visite a Biblioteca de Documentos

Sadagopan Magesh et al.
Bioorganic & medicinal chemistry, 17(13), 4595-4603 (2009-05-20)
Recent advances in the sialidase biology have clarified the role of human sialidases (NEU 1 to NEU4) in the development of various disease states such as cancer, diabetes and arteriosclerosis. Isoform selective human sialidase inhibitors could be a therapeutic tool
Keiko Hata et al.
Antimicrobial agents and chemotherapy, 52(10), 3484-3491 (2008-08-13)
Oseltamivir (Tamiflu) and zanamivir (Relenza), two extensively used clinically effective anti-influenza drugs, are viral sialidase (also known as neuraminidase) inhibitors that prevent the release of progeny virions and thereby limit the spread of infection. Recently mortalities and neuropsychiatric events have
Thomas Haselhorst et al.
Glycobiology, 17(1), 68-81 (2006-09-16)
The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the N-acetylneuraminic acid (Neu5Ac) derivatives has been characterized by saturation transfer difference
Hisaaki Aoki et al.
Pediatrics international : official journal of the Japan Pediatric Society, 55(6), e143-e145 (2013-12-18)
Hemolytic uremic syndrome (HUS) in children is usually caused by Shiga-like toxin-producing Escherichia coli, but approximately 5% of cases are caused by invasive pneumococcal infection (P-HUS). Reported herein is the case of a 9-month-old HUS patient with pneumococcal meningitis who
Santosh Rudrawar et al.
Organic & biomolecular chemistry, 10(43), 8628-8639 (2012-09-15)
Novel 3-C-alkylated-Neu5Ac2en derivatives have been designed to target the expanded active site cavity of influenza virus sialidases with an open 150-loop, currently seen in X-ray crystal structures of influenza A virus group-1 (N1, N4, N5, N8), but not group-2 (N2
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