Pular para o conteúdo
Merck
Todas as fotos(2)

Key Documents

View All Documentation

D5564

Sigma-Aldrich

7,8-Dihydroxycoumarin

≥97%, powder

Sinônimo(s):

Daphnetin, Daphnetol, Ruixiangsu

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(2)

About This Item

Fórmula empírica (Notação de Hill):
C9H6O4
Número CAS:
486-35-1
Peso molecular:
178.14
Número CE:
207-632-8
Número MDL:
MFCD00016977
Código UNSPSC:
12352200
ID de substância PubChem:
24278375
NACRES:
NA.77

fonte biológica

synthetic (organic)

Ensaio

≥97%

forma

powder

solubilidade

ethanol: 5 mg/mL

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

Oc1ccc2C=CC(=O)Oc2c1O

InChI

1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H

chave InChI

ATEFPOUAMCWAQS-UHFFFAOYSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Ações bioquímicas/fisiológicas

7,8-Dihydroxycoumarinan is an inhibitor of protein kinases. It is an active lactone present in plants such as Daphne Korean Nakai, and Thymelaeaceae Daphne. It serves as as analgesic, antiviral and antibacterial agent. 7,8-Dihydroxycoumarinan is found to induce tumor apoptosis via a number of signalling pathways. Thus, it is believed to exhibit antitumor effects. 7,8-Dihydroxycoumarinan might also be useful in treating lung carcinoma. It is also known to be used in treating coagulation disorders and rheumatoid arthritis. 7,8-Dihydroxycoumarinan is known to induce neurite growth and lengthen neuronal survival. It helps in clearing substances inducing necrosis, maintains water-electrolytes balance and energy metabolism. 7,8-Dihydroxycoumarinan is involved in the generation of neurotrophic factor and helps in restoring neuron function.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Neurotrophic effects of 7,8-dihydroxycoumarin in primary cultured rat cortical neurons
Yan L, et al.
Experimental and Therapeutic Medicine, 28(5), 493?498-493?498 (2012)
7, 8-Dihydroxycoumarin inhibits A549 human lung adenocarcinoma cell proliferation by inducing apoptosis via suppression of AktNF-kappaB signaling
Wang Y, et al.
Experimental and Therapeutic Medicine, 5(6), 1770-1774 (2013)
Y Z Yang et al.
The American journal of tropical medicine and hygiene, 46(1), 15-20 (1992-01-01)
Daphnetin is a dihydroxycoumarin that is being used in China for the treatment of coagulation disorders. It is also a chelator and an antioxidant. In vitro, daphnetin causes a 50% inhibition (IC50) of 3H-hypoxanthine incorporation by Plasmodium falciparum at concentrations
7, 8-dihydroxycoumarin may promote sciatic nerve regeneration by suppressing NF-kappaB expression in mice
Du JS, et al.
Molecular Medicine Reports, 8(5), 1525-1530 (2013)
E B Yang et al.
Biochemical and biophysical research communications, 260(3), 682-685 (1999-07-15)
Protein kinases play key roles in the control of cell proliferation, differentiation and metabolism. In this work, we studied the effect of coumarin and its derivatives, including daphnetin, esculin, 2-OH-coumarin, 4-OH-coumarin and 7-OH-coumarin, on the activity of protein kinases. It
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica