C7870

Chalcone 4 hydrate

≥98% (HPLC)

• Sinônimo(s): (E)-1-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one hydrate
• Fórmula empírica (Notação de Hill): C₁₆H₁₃ClO₃ · xH₂O
• Número CAS: 1202866-96-3
• Peso molecular: 288.73 (anhydrous basis)
• Número MDL: MFCD12912407
• Código UNSPSC: 51111800
• ID de substância PubChem: 329775154
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: solid
• condição de armazenamento: protect from light
• cor: yellow
• solubilidade: DMSO: >20 mg/mL
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O.COc1cc(ccc1O)\C=C\C(=O)c2ccc(Cl)cc2
• InChI: 1S/C16H13ClO3.H2O/c1-20-16-10-11(3-9-15(16)19)2-8-14(18)12-4-6-13(17)7-5-12;/h2-10,19H,1H3;1H2/b8-2+;
• chave InChI: PXVQKTVKTBMRIW-VOKCZWNHSA-N

Descrição

Ações bioquímicas/fisiológicas

Chalcone 4 is a potent, selective inhibitor of the chemokine CXCL12 via direct binding. It is also a small molecule anti-ligand (or neutraligand) of CXCR4 and CXCR7.

Chalcone 4 is a potent, selective inhibitor of the chemokine CXCL12 via direct binding. It is also a small molecule anti-ligand (or neutraligand) of CXCR4 and CXCR7. The chemokine CXCL12 (stromal cell-derived factor-1) and its receptors play pivotal roles in inflammatory responses, normal vascular and neuronal development, as well as in infectious diseases and cancer. Chalcone 4 binds to and activates the chemokine receptors CXCR4 and CXCR7 and stimulates a rapid receptor-mediated intracellular calcium mobilization and signaling through a Pertussis toxin sensitive Gi protein. Chalcone 4 potently and selectively inhibits CXCL12 binding to CXCR4 and CXCR7, and consequent CXCL12-evoked calcium cellular responses. Chalcone 4 binds to the chemokine CXCL12, but not to its receptors.

Características e benefícios

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS09
• Palavra indicadora: Warning
• Frases de perigo: H410
• Declarações de precaução: P273 - P501
• Classificações de perigo: Aquatic Acute 1 - Aquatic Chronic 1
• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves