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136123

Sigma-Aldrich

trans-Chalcone

97%

Sinônimo(s):

Benzylideneacetophenone

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About This Item

Fórmula linear:
C6H5CH=CHCOC6H5
Número CAS:
614-47-1
Peso molecular:
208.26
Número CE:
210-383-8
Número MDL:
MFCD00003082
Código UNSPSC:
12352100
ID de substância PubChem:
24848257
NACRES:
NA.22

Nível de qualidade

100

Ensaio

97%

Formulário

solid

p.e.

208 °C/25 mmHg (lit.)

pf

55-57 °C (lit.)

grupo funcional

ketone
phenyl

cadeia de caracteres SMILES

[H]\C(=C(\[H])C(=O)c1ccccc1)c2ccccc2

InChI

1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+

chave InChI

DQFBYFPFKXHELB-VAWYXSNFSA-N

Informações sobre genes

human ... IL1B(3553)
rat ... Ar(24208)

Categorias relacionadas

Descrição geral

trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.

Aplicação

trans-Chalcone was used in the synthesis of cis and trans diphenyl cyclopropane. It was also used in screening of surface adsorbed species of isobutybenzene and 4-isobutylacetophenone on bulk fosfotungstic Wells-Dawson acid (H6P2W18O62.xH2O).

Ações bioquímicas/fisiológicas

trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H319,H335

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
STBK6687
STBJ7806
STBJ5460
STBH4759
STBH3142

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4′-hydroxychalcone AldrichCPR

Sigma-Aldrich

CDS003892

4′-hydroxychalcone

4′-Methoxyacetophenone 99%

Sigma-Aldrich

117374

4′-Methoxyacetophenone

Acetophenone analytical standard

Supelco

42163

Acetophenone

Sylvie Ducki et al.
Bioorganic & medicinal chemistry, 17(22), 7698-7710 (2009-10-20)
The alpha-methyl chalcone SD400 is a potent inhibitor of tubulin assembly and possesses potent anticancer activity. Various chalcone analogues were synthesized and evaluated for their cell growth inhibitory properties against the K562 human chronic myelogenous leukemia cell line (SD400, IC(50)
Wattenberg L.W., et al.
Cancer Letters, 15, 165-165 (1994)
Daniela Batovska et al.
European journal of medicinal chemistry, 44(5), 2211-2218 (2008-07-01)
A large series of chalcones were synthesized and studied against Staphylococcus aureus and Escherichia coli. Chalcones were either unsubstituted in ring A or possessed 4'-chloro or 3',4',5'-trimethoxy groups. Their other ring B was variously substituted. It was found that the
Saeed Attar et al.
Bioorganic & medicinal chemistry, 19(6), 2055-2073 (2011-02-26)
A series of 30 organic chlacones and 33 ferrocenyl (Fc) chalcones were synthesized and characterized by melting point, elemental analysis, spectroscopy ((1)H NMR and FTIR) and, in two cases, by X-ray crystallography. The biological activity of each compound (10(-4)M in
Asha Budakoti et al.
European journal of medicinal chemistry, 44(3), 1317-1325 (2008-04-02)
In an effort to develop potent antiamoebic agents, we have synthesized chalcones (1-8), amino-5-substituted-(3-phenyl(2-pyrazolinyl))methane-1-thione derivatives (1a-8a) and 2-(5-substituted-3-phenyl-2-pyrazolinyl)-1,3-thiazolino[5,4-b]quinoxaline derivatives (1b-8b) and evaluated for their in vitro antiamoebic activity against HM1:IMSS strain of E. histolytica. All the compounds were characterized by
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