C6417

Monoclonal Anti-Cytokeratin Peptide 7 antibody produced in mouse

clone LDS-68, ascites fluid

• Número MDL: MFCD00162253
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• conjugado: unconjugated
• forma do anticorpo: ascites fluid
• tipo de produto de anticorpo: primary antibodies
• clone: LDS-68, monoclonal
• contém: 15 mM sodium azide
• reatividade de espécies: human
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; immunohistochemistry (frozen sections): suitable; indirect immunofluorescence: 1:200 using formalin-fixed, paraffin-embedded sections of human and animal tissue; microarray: suitable; western blot: suitable
• Isotipo: IgG1
• nº de adesão UniProt: P08729
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... KRT7(3855)

Descrição

Descrição geral

Keratin, type II cytoskeletal 7 is a protein encoded by the KRT7 gene in humans. It is also known as cytokeratin-7 (CK-7), keratin-7 (K7), sarcolectin (SCL) and K2C7. Keratin 7 is a type II keratin and is a member of the keratin gene family. It is found on chromosome 12. It is specifically expressed in the simple epithelia lining of the internal organs and in the gland ducts as well as blood vessels.

Monoclonal anti-Cytokeratin Peptide 7 (mouse IgG1 isotype) is derived from the hybridoma produced the fusion of mouse myeloma cells and splenocytes of an immunized mouse. Cytokeratins are the intermediate filaments of endocrine cells. These proteins belongs to the intermediate filament (10 nm) superfamily of cytoskeletal proteins. Cytokeratin 7 (CK 7/ KRT7) is a low molecular weight cytokeratin. It is present in epithelial tissues of lung, breast and ovary.

Especificidade

The antibody reacts specifically with most simple epithelia but shows no reaction with epithelial cells in the intestine or in the stomach.

Imunogênio

cytoskeletal preparation of the RT4 human bladder carcinoma cell line.

Aplicação

Monoclonal Anti-Cytokeratin Peptide 7 antibody produced in mouse has been used in:

• immunohistochemical staining
• western blotting
• immunohistochemistry
• immunofluorescence.

Ações bioquímicas/fisiológicas

Cytokeratins may play an important role in transhepatic transport and canalicular secretion. Cytokeratin 7 (CK 7/ KRT7) only stains bile ducts in normal liver, hence it is considered as “bile duct keratin”. CK 7 is widely used in surgical pathology. It acts as a specific marker for mammary and extramammary Paget′s disease.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable