C5688
Complement factor D from human plasma
90-110 μg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)
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About This Item
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Aplicação
Complement factor D is a serine protease essential for the activation of the alternative pathway in the complement system. Research of complement factor D has revealed that a self inhibitory loop is responsible for switch from a resting to active state. Additionally, recent research has linked a complement factor D gene, single nucleotide polymorphism (SNP) rs3826945, with age-related macular degeneration (AMD). In these AMD cases there was a significant increase in plasma complement factor D concentration, even though previous research has shown no association between complement factor D SNP genes and AMD.
Ações bioquímicas/fisiológicas
Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue.
Nota de análise
Source plasma tested for HBSAg, HCV, HBC, syphillis, and HIV-1/HIV-2
Outras notas
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Exoneração de responsabilidade
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Nº do produto
Descrição
Preços
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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M A Niemann et al.
Journal of immunology (Baltimore, Md. : 1950), 132(2), 809-815 (1984-02-01)
The monoclonal antibodies (MAb) were studied for their binding specificities and their effects on the hemolytic and proteolytic activities of human D. One Mab, FD10-1, was obtained from mice immunized with native D; the other, JA4-2, was similarly obtained from
Jiexi Zeng et al.
Molecular vision, 16, 2273-2278 (2010-12-09)
Age-related macular degeneration (AMD) is the most common cause of irreversible central vision loss worldwide. Research has linked AMD susceptibility with dysregulation of the complement cascade. Typically, complement factor H (CFH), complement factor B (CFB), complement component 2 (C2), and
Chloe M Stanton et al.
Investigative ophthalmology & visual science, 52(12), 8828-8834 (2011-10-18)
To examine the role of complement factor D (CFD) in age-related macular degeneration (AMD) by analysis of genetic association, copy number variation, and plasma CFD concentrations. Single nucleotide polymorphisms (SNPs) in the CFD gene were genotyped and the results analyzed
H Jing et al.
Journal of molecular biology, 282(5), 1061-1081 (1998-10-01)
Factor D is a serine protease essential for the activation of the alternative pathway of complement. The structures of native factor D and a complex formed with isatoic anhydride inhibitor were determined at resolution of 2.3 and 1.5 A, respectively
Shin Yong Park et al.
Journal of immunology (Baltimore, Md. : 1950), 181(9), 6328-6336 (2008-10-23)
Enterococcus faecalis (Ef) accounts for most cases of enterococcal bacteremia, which is one of the principal causes of nosocomial bloodstream infections (BSI). Among several virulence factors associated with the pathogenesis of Ef, an extracellular gelatinase (GelE) has been known to
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