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C4895

Sigma-Aldrich

Cephalexin hydrate

first-generation cephalosporin antibiotic

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About This Item

Fórmula empírica (Notação de Hill):
C16H17N3O4S · xH2O
Número CAS:
1820673-23-1
Peso molecular:
347.39 (anhydrous basis)
Beilstein:
965503
Número CE:
239-773-6
Número MDL:
MFCD00056877
Código UNSPSC:
51282503
ID de substância PubChem:
24278316
NACRES:
NA.85

forma

powder

pKa 

5.2
7.3

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria

Modo de ação

cell wall synthesis | interferes

temperatura de armazenamento

2-8°C

InChI

1S/C16H17N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);1H2/t10-,11-,15?;/m1./s1

chave InChI

AVGYWQBCYZHHPN-FNOHQHCYSA-N

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Categorias relacionadas

Descrição geral

Chemical structure: ß-lactam

Aplicação

Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

Ações bioquímicas/fisiológicas

Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.

Outras notas

Storage of this product should be in airtight containers and protected from light.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H317,H334

Classificações de perigo

Resp. Sens. 1 - Skin Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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