C2866
Anti-Cannabinoid Receptor 1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
reatividade de espécies
human
disponibilidade
not available in Japan
técnica(s)
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 8-11 μg/mL
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CNR1(1268)
mouse ... Cnr1(12801)
rat ... Cnr1(25248)
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Descrição geral
Cannabinoid receptor type 1 (CNR1) is a G protein-coupled cannabinoid receptor found in central and peripheral nervous system. CNR1 belongs to rhodopsin-like G protein-coupled receptor superfamily.
Imunogênio
synthetic peptide corresponding to the third cytoplasmic loop of human cannabinoid receptor 1, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
Aplicação
Anti-Cannabinoid Receptor 1 antibody produced in rabbit is suitable for immunocytochemistry and immunohistochemistry using formalin-fixed and paraffin-embedded sections at a concentration of 8-11μg/mL.
Ações bioquímicas/fisiológicas
CNR1 has implications in several disease states, including drug addiction, anxiety, depression, obesity, and chronic pain. Different classes of CNR1 agonists are involved in signaling pathways through the activation of specific subtypes of G proteins. It may play a key role for the treatment of negative affective state produced by alcohol withdrawal and abstinence which is critical for the maintenance of alcohol addiction. CNR1 genes also play some roles in common polymorphism (rs1049353) with potential implications in weight loss.
forma física
Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Joong-Youn Shim et al.
The Journal of biological chemistry, 288(45), 32449-32465 (2013-10-05)
The cannabinoid (CB1) receptor is a member of the rhodopsin-like G protein-coupled receptor superfamily. The human CB1 receptor, which is among the most expressed receptors in the brain, has been implicated in several disease states, including drug addiction, anxiety, depression
Jenny Ceccarini et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(8), 2822-2831 (2014-02-21)
Involvement of the type 1 cannabinoid receptor (CB1R) in the effects of alcohol on the brain is supported by animal experiments, but how in vivo CB1R levels are altered in alcoholic patients is still unclear. To assess the short-time effects
Daniel Antonio de Luis et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 62(2), 324-327 (2013-12-11)
A polymorphism (1359 G/A) of the cannabinoid receptor 1 (CNR1) gene was reported as a common polymorphism (rs1049353) with potential implications in weight loss. We decide to investigate the role of this polymorphism on metabolic changes and weight loss secondary
Xue Shen et al.
BioMed research international, 2019, 5468954-5468954 (2019-02-26)
Adenomyosis is a common gynecologic benign disease that may have a life-long negative impact on women. Previous studies have indicated that the endocannabinoid system may participate in the progress of endometriosis. Our research aims to analyze the expression patterns of
Xian-Dong Meng et al.
International journal of clinical and experimental pathology, 7(6), 2825-2837 (2014-07-18)
Cannabinoid type 1 receptor (CB1R), which is traditionally located on axon terminals, plays an important role in the pathology of epilepsy and neurodegenerative diseases by modulating synaptic transmission. Using the pilocarpine model of chronic spontaneous recurrent seizures, which mimics the
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