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C2374

Sigma-Aldrich

Cyclo-Gly-Pro

≥98% (GC/HPLC)

Sinônimo(s):

(S)-3,6-Dioxohexahydropyrrolo[1,2-a]pyrazine, Glycyl-L-proline lactam, cyclo-GP, cyclo-Glycyl-L-Proline, cyclo-L-prolylglycine

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About This Item

Fórmula empírica (Notação de Hill):
C7H10N2O2
Número CAS:
3705-27-9
Peso molecular:
154.17
Número MDL:
MFCD01083707
Código UNSPSC:
12352200
ID de substância PubChem:
329774997
NACRES:
NA.32

Nível de qualidade

100

Ensaio

≥98% (GC/HPLC)

forma

powder

solubilidade

DMSO: >10 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O=C1CNC(=O)C2CCCN12

InChI

1S/C7H10N2O2/c10-6-4-8-7(11)5-2-1-3-9(5)6/h5H,1-4H2,(H,8,11)

chave InChI

OWOHLURDBZHNGG-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

Cyclo-Gly-Pro is a neuro-protective compound, an endogenous diketopiperazine, which enhances memory. In the animal model of PD, the compound improved functional recovery when administered after the onset of dyskinesia. It appears that the compound recovery function may result from non-proliferative neurogenesis that results from the inhibition of apoptosis of stem cells and/or the promotion of neuronal-orientated proliferation in the SVZ (subventricular zone).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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J Guan et al.
Neuropharmacology, 53(6), 749-762 (2007-10-02)
The current study describes the neuroprotective effects of an endogenous diketopiperazine, cyclo-glycyl-proline (cyclic GP), in rats with hypoxic-ischemic brain injury and the pre-clinical development of an analogue, cyclo-L-glycyl-L-2-allylproline (NNZ 2591), modified for improved bioavailability. The compounds were given either intracerebroventricularly
Douglas R Houston et al.
Journal of medicinal chemistry, 47(23), 5713-5720 (2004-10-29)
Family 18 chitinases play an essential role in a range of pathogens and pests. Several inhibitors are known, including the potent inhibitors argadin and allosamidin, and the structures of these in complex with chitinases have been elucidated. Recent structural analysis
J Tritt-Goc et al.
International journal of peptide and protein research, 34(4), 299-305 (1989-10-01)
The complexation of cyclo(Pro17O-Gly15N) and cyclo(Gly17O-Pro) with Co2+ ions has been studied by 17O, 14N and 15N n.m.r. spectroscopy in aqueous solution. 17O, 14N and 15N transverse relaxation times and chemical shifts were measured as a function of temperature. The
F Sussman et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(20), 7880-7884 (1989-10-01)
Calcium plays a crucial role in many cellular processes. Its functions are directly dependent on the high specificity for Ca2+ exhibited by the proteins and ion carriers that bind divalent ions. To elucidate the basis for this specificity we have
Z-F Wu et al.
Scandinavian journal of immunology, 76(2), 131-140 (2012-05-23)
This study was undertaken to isolate active secondary metabolites from immunostimulatory Alcaligenes faecalis FY-3 and evaluate their activities using grass carp Ctenopharyngodon idella kidney (CIK) cells. By applying chromatography techniques and successive recrystallization, three purified metabolites were obtained and identified

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