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C160

Sigma-Aldrich

CGP-42112A

≥95%, synthetic, solid

Sinônimo(s):

Nα-Nicotinoyl-Tyr-(Nα-Cbz-Arg)-Lys-His-Pro-Ile

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About This Item

Fórmula empírica (Notação de Hill):
C52H69N13O11
Número CAS:
127060-75-7
Peso molecular:
1052.18
Beilstein:
8184948
Número MDL:
MFCD00133611
Código UNSPSC:
12352200
ID de substância PubChem:
24892424
NACRES:
NA.77

fonte biológica

synthetic

Nível de qualidade

200

Ensaio

≥95%

Formulário

solid

cor

white

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O

InChI

1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1

chave InChI

UXGNARZDONUMMK-LRMQDCNJSA-N

Informações sobre genes

human ... AGTR2(186)
rat ... AGTR2(11609)

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Amino Acid Sequence

Tyr-Z-Arg-Lys-His-Pro-Ile

Aplicação

CGP-42112A has been used:
  • in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
  • to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
  • as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

Ações bioquímicas/fisiológicas

CGP-42112A is a potent angiotensin II type 2 receptor (AT2R) agonist.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
SLCL1541
SLCK9693
SLCK4293
SLCD4997
SLBZ5320

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Nancy J Hong et al.
Hypertension (Dallas, Tex. : 1979), 60(3), 765-769 (2012-07-11)
NO reduces NaCl absorption by thick ascending limbs (TALs) by inhibiting the Na/K/2Cl cotransporter (NKCC2). We have shown that NO-induced inhibition of Na transport is reduced in Dahl salt-sensitive rat (SS) TALs. Angiotensin II increases NO production in TALs via
E Chamoux et al.
The Journal of clinical endocrinology and metabolism, 84(12), 4722-4730 (1999-12-22)
The aim of this study was to establish a link between the highly expressed angiotensin II (Ang II) type 2 receptor (AT2) in human fetal adrenal cells and the proposed apoptotic activity in the center of the gland. There was
Anu Vaajanen et al.
Investigative ophthalmology & visual science, 49(6), 2557-2562 (2008-01-29)
In the present study the effects of exogenous angiotensin II and its breakdown metabolite angiotensin (1-7) on the intraocular pressure (IOP) and on aqueous humor dynamics in normotensive rabbit eye were evaluated. Male New Zealand White rabbits with normal IOP
C Sumners et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(17), 7567-7571 (1991-09-01)
Both neurons and astrocytes contain specific receptors for angiotensin II (AII). We used selective ligands for the AT1 and AT2 types of AII receptors to investigate the expression of functional receptor subtypes in astrocyte cultures and neuron cultures from 1-day-old
L Laflamme et al.
The Journal of biological chemistry, 271(37), 22729-22735 (1996-09-13)
In the present study, 3-day treatment of nondifferentiated NG108-15 cells with 100 nM angiotensin II (Ang II) induces morphological differentiation of neuronal cells characterized by the outgrowth of neurites. These morphological changes are correlated with an increase in the level
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