C1354
Monoclonal Anti-Caspase 11 antibody produced in rat
clone 17D9, purified from hybridoma cell culture
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About This Item
Produtos recomendados
fonte biológica
rat
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
17D9, monoclonal
Formulário
buffered aqueous solution
reatividade de espécies
mouse
embalagem
antibody small pack of 25 μL
concentração
~1 mg/mL
técnica(s)
immunoblotting: 5-10 μg/mL using mouse EL4 cell extracts.
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
Isotipo
IgG2a
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
mouse ... Casp4(12363)
Descrição geral
Caspases are proteases having similar structure, substrate specificity and can be divided into three subfamilies based upon their amino acid sequence homology.Monoclonal Anti-Caspase 11 (rat IgG2a isotype) is derived from the 17D9 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a recombinant p30 subunit of mouse caspase 11. Caspase 11 (also known as Ich-3) gene encodes two protein products of 38 and 43 kDa that belong to the Ced3/ICE family of cystein proteases. Caspase 11 is an “upstream” caspase with a long prodomain. Caspase 11 is identified in murine and shares homology with the human caspase 4 and 5.
Imunogênio
recombinant p30 subunit of mouse caspase 11.
Aplicação
Monoclonal Anti-Caspase 11 antibody can be used in immunohistochemistry and immunoprecipitation. It is also useful in immunoblotting
Ações bioquímicas/fisiológicas
Caspases are normally produced in the cell as inactive procaspases. Caspase 11 can induce apoptosis in cultured cells due to overexpression. Monoclonal antibodies reacting specifically with caspase 11 are useful tool for the study of the protease network, involved in development and regulation, governing the life and death of cells and tissues.
forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Arwa Abu Khweek et al.
Cellular immunology, 370, 104425-104425 (2021-11-21)
Asthma is an inflammatory lung disorder characterized by mucus hypersecretion, cellular infiltration, and bronchial hyper-responsiveness. House dust mites (HDM) are the most prevalent cause of allergic sensitization. Canonical and noncanonical inflammasomes are multiprotein complexes that assemble in response to pathogen
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Chuang Yuan et al.
Cell death & disease, 13(8), 722-722 (2022-08-19)
Sepsis is a life-threatening syndrome with disturbed host responses to severe infections, accounting for the majority of death in hospitalized patients. However, effective medicines are currently scant in clinics due to the poor understanding of the exact underlying mechanism. We
Caspase-11: the driving factor for noncanonical inflammasomes
Vigano E and Mortellaro A
European Journal of Immunology, 43(9), 2240-2245 (2013)
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