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B4559

Sigma-Aldrich

BRL 44408 maleate salt

≥98% (HPLC)

Sinônimo(s):

2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt

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About This Item

Fórmula empírica (Notação de Hill):
C17H21N3O4
Número CAS:
118343-19-4
Peso molecular:
331.37
Número MDL:
MFCD02262218
Código UNSPSC:
12352200
ID de substância PubChem:
329773239
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

cor

white to beige

solubilidade

H2O: soluble 15 mg/mL, clear

originador

GlaxoSmithKline

cadeia de caracteres SMILES

OC(=O)\C=C/C(O)=O.CC1N(CC2=NCCN2)Cc3ccccc13

InChI

1S/C13H17N3.C4H4O4/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13;5-3(6)1-2-4(7)8/h2-5,10H,6-9H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-

chave InChI

DDIQGSUEJOOQQQ-BTJKTKAUSA-N

Ações bioquímicas/fisiológicas

BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.

Características e benefícios

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações legais

Sold under agreement from Glaxo­Smith­Kline

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Zoltán S Zádori et al.
Neurochemistry international, 51(5), 297-305 (2007-08-01)
The inhibitory effect of clonidine (non-selective alpha2-adrenoceptor agonist) and oxymetazoline (alpha2A-adrenoceptor selective agonist) was compared on basal and stimulated gastric motor activity (gastric tone and contractions) using the balloon method in the rat. It was shown that oxymetazoline (0.2-1.7 micromol/kg
Mu-huo Ji et al.
Cytokine, 60(3), 639-645 (2012-09-11)
To investigate the effects of α2A-adrenoreceptor blockade on acute lung injury (ALI) and high mobility group box-1 protein (HMGB1) expression in a rat model of sepsis. Sepsis was induced in male rats by cecal ligation and puncture (CLP). Thirty adult
Junta Imaki et al.
Neuroscience letters, 454(2), 143-147 (2009-05-12)
We examined the effects of JP-1302 (a selective alpha2C antagonist), BRL-44408 (a selective alpha2A antagonist) and yohimbine (a non-selective alpha2 antagonist) on haloperidol-induced bradykinesia and catalepsy in mice to elucidate the role of alpha2 adrenoceptor subtypes in modifying extrapyramidal motor
Shawquia Young et al.
Basic & clinical pharmacology & toxicology, 107(2), 690-697 (2010-04-01)
Previously, we reported that antinociceptive synergism of a 5-HT(3)/alpha(2)-adrenoceptor ligand MD-354 (m-chlorophenylguanidine) and clonidine combination occurs, in part, through a 5-HT(3) receptor antagonist mechanism. In the present investigation, a possible role for alpha(2)-adrenoceptors was examined. Mechanistic studies using yohimbine (a
Roberto T Sudo et al.
The journal of pain : official journal of the American Pain Society, 11(1), 71-78 (2009-10-27)
Finding new chemicals or adjuvants with analgesic effects in the central nervous system is clinically relevant due to the limited number of drugs with these properties. Here, we present PT-31, which is chemically related to 3-benzyl-imidazolidine, with an analgesic profile
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α2-Adrenoceptors

α2-Adrenoceptors

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