B2938

BEPP monohydrochloride

≥98% (HPLC)

• Sinônimo(s): 1H-Benzimidazole-1-ethanol, 2,3-dihydro-2-imino-alpha-(phenoxymethyl)-3-(phenylmethyl)- monohydrochloride
• Fórmula empírica (Notação de Hill): C₂₃H₂₃N₃O₂ HCl
• Número CAS: 455311-98-5
• Peso molecular: 409.91
• Número MDL: MFCD00964481
• Código UNSPSC: 12352200
• ID de substância PubChem: 329773209
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• condição de armazenamento: desiccated
• cor: white to off-white
• solubilidade: DMSO: >10 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.OC(COc1ccccc1)CN2C(=N)N(Cc3ccccc3)c4ccccc24
• InChI: 1S/C23H23N3O2.ClH/c24-23-25(15-18-9-3-1-4-10-18)21-13-7-8-14-22(21)26(23)16-19(27)17-28-20-11-5-2-6-12-20;/h1-14,19,24,27H,15-17H2;1H
• chave InChI: KDMXJFUGIDGZQL-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable