About This Item
Código UNSPSC:
41116158
NACRES:
NA.84
Produtos recomendados
forma do anticorpo
purified antibody
Nível de qualidade
reatividade de espécies
mouse, human
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
Descrição geral
A Protein Conformational Array (PCA) in a sandwich ELISA format where the plate is coated with a panel of antibodies raised against peptides derived from the full-length protein sequence of Aflibercept. Taken individually, each of these antibodies is strongly antigenic to the peptide sequence that was used in its production. However, when these peptides are incorporated into a full length correctly folded protein, the antigenicity of many of them is masked by the three-dimensional structure of the protein and only a limited number of the antibodies respond. The result is a histogram which can be likened to a ‘fingerprint′ for correctly folded Aflibercept. For a Eylea Biosimilar, if the protein is correctly folded and glycosylated, the ‘fingerprint′ will match that of Aflibercept. If it is not correctly folded, previously masked peptide sequences will be exposed and will be recognized by the antibody made to that exposed sequence. In this way, changes in the ‘fingerprint′ generated by the ELISA will point out differences between the Biosimilar and authentic Aflibercept.
Aplicação
For research use only. Not for use in diagnostic procedures.
Outras notas
ELISA kit contains 3 96-well microplates and all the components necessary to complete an ELISA test.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
Código de classe de armazenamento
8B - Non-combustible corrosive hazardous materials
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Certificados de análise (COA)
Lot/Batch Number
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