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Key Documents

A9965

Sigma-Aldrich

N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin

≥95% (HPLC), powder

Sinônimo(s):

Ac-YVAD-AFC

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About This Item

Fórmula linear:
C33H36N5O10F3
Peso molecular:
719.66
Número MDL:
Código UNSPSC:
12352209
ID de substância PubChem:
NACRES:
NA.32

Ensaio

≥95% (HPLC)

forma

powder

cor

white

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2

InChI

1S/C33H36F3N5O10/c1-15(2)28(41-31(49)23(38-17(4)42)11-18-5-8-20(43)9-6-18)32(50)37-16(3)29(47)40-24(14-26(44)45)30(48)39-19-7-10-21-22(33(34,35)36)13-27(46)51-25(21)12-19/h5-10,12-13,15-16,23-24,28,43H,11,14H2,1-4H3,(H,37,50)(H,38,42)(H,39,48)(H,40,47)(H,41,49)(H,44,45)/t16-,23-,24-,28-/m0/s1

chave InChI

GWKJISJKNKIJNP-DEQDFGQZSA-N

Informações sobre genes

Amino Acid Sequence

NAc-Tyr-Val-Ala-Asp-AFC

Substratos

Membrane-permeable fluorogenic substrate for caspase 1 (ICE) and caspase 4 (TX).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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Emma M Creagh et al.
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R A Jones et al.
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The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant nuclear distribution of TDP-43 in the

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