A7191

N-Acetyl-D-sphingosine

≥97% (TLC), powder

• Sinônimo(s): (2S,3R,4E)-2-(Acetylamino)-4-octadecene-1,3-diol, N-Acetoyl-D-erythro-sphingosine, Acetyl ceramide, C2 Ceramide (d18:1/2:0), C₂ ceramide
• Fórmula empírica (Notação de Hill): C₂₀H₃₉NO₃
• Peso molecular: 341.53
• Número MDL: MFCD00153903
• Código UNSPSC: 12352211
• ID de substância PubChem: 24891187
• NACRES: NA.77

Propriedades

• fonte biológica: semisynthetic
• Ensaio: ≥97% (TLC)
• Formulário: powder
• cor: white
• solubilidade: DMSO: soluble; ethanol: soluble
• tipo de lipídio: sphingolipids
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CCCCCCCCCCCCC\C=C\[C@H](O)[C@@H](CO)NC(C)=O
• InChI: 1S/C20H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h15-16,19-20,22,24H,3-14,17H2,1-2H3,(H,21,23)/b16-15+/t19-,20+/m1/s1
• chave InChI: BLTCBVOJNNKFKC-HEQKZDDYSA-N

Descrição

Aplicação

N-Acetyl-D-sphingosine is a cell-permeable and biologically active ceramide. N-Acetyl-D-sphingosine induces differentiation and apoptosis in cells. N-Acetyl-D-sphingosine produces concentration-dependent impairment of vasorelaxation in response to the endothelium-dependent agonist acetylcholine in nontransgenic mice.

Ações bioquímicas/fisiológicas

Cell-permeable, biologically active ceramide. It induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases.

Nota de preparo

Prepared from D-sphingosine from bovine brain cerebrosides.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)