A6563
6-Anilinoquinoline-5,8-quinone
≥95% (TLC), solid
Sinônimo(s):
6-(Phenylamino)-5,8-quinolinedione, LY-83,583, LY83583
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About This Item
Fórmula empírica (Notação de Hill):
C15H10N2O2
Número CAS:
Peso molecular:
250.25
Número MDL:
Código UNSPSC:
41106305
ID de substância PubChem:
NACRES:
NA.77
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Ensaio
≥95% (TLC)
Formulário
solid
cor
violet
solubilidade
0.1 M HCl: 1 mg/mL
methanol: 11 mg/mL
ethanol: 8 mg/mL
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
O=C1C=C(Nc2ccccc2)C(=O)c3cccnc13
InChI
1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H
chave InChI
GXIJYWUWLNHKNW-UHFFFAOYSA-N
Aplicação
6-Anilinoquinoline-5,8-quinone inhibits soluble guanylate cyclase and cGMP production. 6-Anilinoquinoline-5,8-quinone also blocks the release of intracellular Ca2+ and antigen-induced leukotrienes.
Ações bioquímicas/fisiológicas
Blocks cGMP production; inhibits intracellular Ca2+ release; blocks the effects of nitric oxide. Inhibits antigen-induced leukotriene release.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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the aim of this study was to determine the relative importance of Ca(2+) sensitization, ion channels, and intracellular Ca(2+) ([Ca(2+)](i)) in the mixed constrictor/relaxation actions of superoxide anion on systemic and pulmonary arteries. pulmonary and mesenteric arteries were obtained from
Greg A Knock et al.
Free radical biology & medicine, 46(5), 633-642 (2008-12-24)
Reactive oxygen species play a key role in vascular disease, pulmonary hypertension, and hypoxic pulmonary vasoconstriction. We investigated contractile responses, intracellular Ca(2+) ([Ca(2+)](i)), Rho-kinase translocation, and phosphorylation of the regulatory subunit of myosin phosphatase (MYPT-1) and of myosin light chain
I Fleming et al.
British journal of pharmacology, 103(1), 1047-1052 (1991-05-01)
1. The aim of this investigation was to study the relationship between contractile responsiveness, activation of the L-arginine pathway and tissue levels of guanosine 3':5'cyclic monophosphate (cylic GMP) in aortic rings removed from rats 4 h after intraperitoneal administration of
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