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A1104

Sigma-Aldrich

Anti-Angiopoietin-1 antibody produced in goat

affinity isolated antibody, lyophilized powder

Sinônimo(s):

Anti-ANG-1

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About This Item

Número MDL:
MFCD06798694
Código UNSPSC:
51111800
NACRES:
NA.41

fonte biológica

goat

Nível de qualidade

200

recombinante

expressed in goat

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

lyophilized powder

reatividade de espécies

human

técnica(s)

immunohistochemistry: 5-15 μg/mL using cells and tissues
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL

nº de adesão UniProt

Q15389

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ANGPT1(284)

Descrição geral

Angiopoietin 1 is an endothelial cell-specific protein that is a ligand for the TIE2 tyrosine receptor. Angiopoietin 1 is critical for mature blood vessel formation.
Angiopoietin-1 (ANG-1) activates Tie-2 signaling in endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth, and stabilization,. ANG-1 is closely related to ANG-2. Both ANG-1 and ANG-2, with their receptor Tie-2, regulate embryonic vasculogenesis and angiogenisis, adult angiogenic sprouting, as well as endothelial cell proliferation.

Imunogênio

purified, NSO-derived, recombinant human ANG-1.

Aplicação

Goat anti-angiopoietin-1 can be used for immunohistochemistry (5-15 μg/mL), indirect ELISA (0.5-1.0 μg/mL) and western blot (0.1-0.2 μg/mL).

forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Preços

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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N Jones et al.
Nature reviews. Molecular cell biology, 2(4), 257-267 (2001-04-03)
Angiogenesis is required for normal embryonic vascular development and aberrant angiogenesis contributes to several diseases, including cancer, diabetes and tissue ischaemia. What are the molecular mechanisms that regulate this important process? The Tie family of receptors and their ligands, the
L M Orre et al.
Oncogene, 32(49), 5531-5540 (2013-06-12)
S100A4 is a small calcium-binding protein that is commonly overexpressed in a range of different tumor types, and it is widely accepted that S100A4 has an important role in the process of cancer metastasis. In vitro binding assays has shown
P C Maisonpierre et al.
Science (New York, N.Y.), 277(5322), 55-60 (1997-07-04)
Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell-specific Tie2 receptor tyrosine kinase. Like vascular endothelial growth factor, Ang1 is essential for normal
B Witzenbichler et al.
The Journal of biological chemistry, 273(29), 18514-18521 (1998-07-11)
Angiopoietin-1 and its putative natural antagonist, angiopoietin-2, were recently isolated, and the critical role of angiopoietin-1 in embryogenic angiogenesis was demonstrated by targeted gene disruption. Specific biological effects of angiopoietin-1, however, have yet to be defined. In this study we
Natalie R Leach et al.
Virology, 406(1), 127-137 (2010-08-03)
The nuclear lamina is thought to be a steric barrier to the herpesvirus capsid. Disruption of the lamina accompanied by phosphorylation of lamina proteins is a conserved feature of herpesvirus infection. In HSV-1-infected cells, protein kinase C (PKC) alpha and
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