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54880

Sigma-Aldrich

3-Hydroxybenzylhydrazine dihydrochloride

≥98.0% (HPLC)

Sinônimo(s):

α-Hydrazino-m-cresol dihydrochloride, 3-(Hydrazinomethyl)phenol dihydrochloride, NSD-1015

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About This Item

Fórmula linear:
HOC6H4CH2NHNH2 · 2HCl
Número CAS:
81012-99-9
Peso molecular:
211.09
Beilstein:
9282965
Número CE:
279-659-3
Número MDL:
MFCD00044695
Código UNSPSC:
12352202
ID de substância PubChem:
24878937

Nível de qualidade

100

Ensaio

≥98.0% (HPLC)

forma

solid

pf

137-140 °C
138-140 °C (lit.)

solubilidade

H2O: 50 mg/mL, slightly hazy, faintly yellow

cadeia de caracteres SMILES

Cl[H].Cl[H].NNCc1cccc(O)c1

InChI

1S/C7H10N2O.2ClH/c8-9-5-6-2-1-3-7(10)4-6;;/h1-4,9-10H,5,8H2;2*1H

chave InChI

ONOJPUDFIOEGCX-UHFFFAOYSA-N

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Ações bioquímicas/fisiológicas

Inhibitor of L-aromatic amino acid decarboxylase; crosses blood brain barrier. Also inhibits GABA aminotransferase, as well as other pyridoxal-phosphate-requiring enzymes, by forming the 3-hydroxybenzylhydrazone of that cofactor.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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V Mosienko et al.
Translational psychiatry, 2, e122-e122 (2012-07-27)
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Adrian M Russo et al.
Behavioural brain research, 359, 918-926 (2018-06-24)
Autism spectrum disorder (ASD) is a heterogeneous and highly heritable condition with multiple aetiologies. Although the biological mechanisms underlying ASD are not fully understood, evidence suggests that dysregulation of serotonergic systems play an important role in ASD psychopathology. Preclinical models
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