380R-2

Arginase-1 (EP261) Rabbit Monoclonal Primary Antibody

• Código UNSPSC: 12352203

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100; 500
• conjugado: unconjugated
• forma do anticorpo: culture supernatant
• tipo de produto de anticorpo: primary antibodies
• clone: EP261, monoclonal
• descrição: For In Vitro Diagnostic Use in Select Regions
• Formulário: buffered aqueous solution
• reatividade de espécies: human
• embalagem: vial of 0.1 mL concentrate (380R-24); vial of 0.1 mL concentrate Research Use Only (380R-24-RUO); vial of 0.5 mL concentrate (380R-25); vial of 1.0 mL concentrate (380R-26); vial of 1.0 mL concentrate Research Use Only (380R-26-RUO); vial of 1.0 mL pre-dilute Research Use Only (380R-27-RUO); vial of 1.0 mL pre-dilute ready-to-use (380R-27); vial of 7.0 mL pre-dilute ready-to-use (380R-28); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (380R-28-RUO)
• fabricante/nome comercial: Cell Marque^™
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)
• Isotipo: IgG
• controle: hepatocellular carcinoma, normal liver
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• visualização: cytoplasmic, nuclear
• Informações sobre genes: human ... ARG1(383)

Descrição

Descrição geral

Arginase-1 is a key urea cycle metalloenzyme that has demonstrated expression in normal human liver with a high degree of specificity. Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver accounting for an estimated 70%-85% of total liver cancers worldwide. Diagnostic pitfalls exist in the morphologic distinction of HCC from other hepatocellular and non-hepatocellular lesions. In difficult or equivocal cases, the application of immunohistochemical (IHC) panels has been shown to aid in the distinction of benign and malignant liver lesions. In sections of normal liver, anti-arginase-1 produced strong, diffuse cytoplasmic reactivity in all hepatocytes throughout the lobule. In some cases, patchy nuclear reactivity is also evident in hepatocytes along with the cytoplasmic reactivity. Reactivity is not observed in bile duct epithelial cells, sinusoidal endothelial cells, Kupffer cells, or vascular endothelial cells. In sections of HCC, anti-arginase-1 produces cytoplasmic or cytoplasmic plus nuclear reactivity.

Qualidade

IVD

IVD

IVD

RUO

Ligação

Arginase-1 Positive Control Slides, Product No. 380S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparo

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Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable