276M-9

Ksp-cadherin (MRQ-33) Mouse Monoclonal Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100; 500
• conjugado: unconjugated
• forma do anticorpo: culture supernatant
• tipo de produto de anticorpo: primary antibodies
• clone: MRQ-33, monoclonal
• descrição: For In Vitro Diagnostic Use in Select Regions (See Chart)
• forma: buffered aqueous solution
• reatividade de espécies: human
• embalagem: vial of 0.1 mL concentrate (276M-94); vial of 0.5 mL concentrate (276M-95); bottle of 1.0 mL predilute (276M-97); vial of 1.0 mL concentrate (276M-96); bottle of 7.0 mL predilute (276M-98)
• fabricante/nome comercial: Cell Marque^™
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• Isotipo: IgG1
• controle: kidney
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• visualização: membranous
• Informações sobre genes: human ... CDH16(1014)

Descrição

Descrição geral

Kidney-specific cadherin (Ksp-cadherin) is a novel, kidney-specific member of the cadherin family of cell adhesion molecules. Within the kidney, Ksp-cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Different cadherins, including E-cadherin, cadherin-6, and N-cadherin, have been investigated in renal cell cancers, demonstrating possible correlations of tumor dedifferentiation and the presence of lymph node metastasis with loss of cadherins. Mazal et al. investigated the utility of using Ksp-cadherin to distinguish chromophobe renal cell carcinoma from oncocytoma. He found a membranous pattern of staining in 96% of 30 chromophobe carcinomas, and in only 6% of 31 oncocytomas leading them to conclude that this is a useful antibody in differentiating these two lesions. Shen et al., on the other hand, found Ksp-cadherin positivity in 100% of 13 chromophobe RCCs, and 95% of 20 oncocytomas.

Associated products: CK7, RCC

Qualidade

IVD

IVD

IVD

RUO

Ligação

Ksp-cadherin Positive Control Slides, Product No. 276S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany