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Documentos Principais

Y0000591

Vinpocetine impurity B

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

Methyl (13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate, Apovincamine

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About This Item

Fórmula empírica (Notação de Hill):
C21H24N2O2
Número CAS:
4880-92-6
Peso molecular:
336.43
Código UNSPSC:
41116107
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

vinpocetine

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[n]21c3c(c4c2[C@H]5N(CCC[C@]5(C=C1C(=O)OC)CC)CC4)cccc3

InChI

1S/C21H24N2O2/c1-3-21-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(18(15)19(21)22)17(13-21)20(24)25-2/h4-5,7-8,13,19H,3,6,9-12H2,1-2H3/t19-,21+/m1/s1

chave InChI

OZDNDGXASTWERN-CTNGQTDRSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Vinpocetine impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

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Lot/Batch Number

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I Moldvai et al.
Archiv der Pharmazie, 330(6), 190-198 (1997-06-01)
(+)-Vincamine (1) and (+)-vinpocetine (2) were chlorosulfonylated and the resulting sulfonyl chloride isomers (3-6) were transformed into sulfonamides (7-10). The ester group of sulfonamides was modified by selective hydrolysis and transesterification. Apovincaminol derivatives (14-16) were also prepared by reduction. In
M Jucker et al.
Neurobiology of aging, 11(1), 39-46 (1990-01-01)
Changes in the pericapillary microenvironment of adult (18-month-old) and senescent (27 1/2-month-old) Fischer-344 rats treated for 6 weeks with daily IP injections of brovincamine or apovincamine (0, 2.5, 5, 10 mg/kg) were correlated with spontaneous locomotor activity and [14C]-2-deoxyglucose uptake
Koichiro Koyama et al.
Bioorganic & medicinal chemistry, 18(12), 4415-4421 (2010-06-26)
Eight new indole alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods. Alpneumines E and G (5 and 7), vincamine, and apovincamine showed anti-melanogenesis in

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