SMB01325

Albendazole sulfoxide

≥97% (HPLC)

• Sinônimo(s): Ricobendazole, Albendazole oxide, Albendazole sulfoxide, Methyl [5-(propane-1-sulfinyl)-1H-benzoimidazol-2-yl]-carbamate
• Fórmula empírica (Notação de Hill): C₁₂H₁₅N₃O₃S
• Número CAS: 54029-12-8
• Peso molecular: 281.33
• Beilstein: 677664
• Número MDL: MFCD00797922
• Código UNSPSC: 12352119
• NACRES: NA.77

Propriedades

• descrição: Modulation and Signaling
• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• forma: solid
• cor: white to beige
• adequação: HPTLC
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CCCS(=O)c1ccc2[nH]c(NC(=O)OC)nc2c1
• InChI: 1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
• chave InChI: VXTGHWHFYNYFFV-UHFFFAOYSA-N

Descrição

Descrição geral

Albendazole sulfoxide is a blood-brain barrier main metabolite of anti-parasitic agent albendazole that acts as a antihelminthic. It binds to colchicine binding site of β-tubulin and prevents polymerization. Albendazole sulfoxide exhibits greater affinity to parasitic β-tubulin than to mammalian.

Aplicação

Metabolomics research

Ações bioquímicas/fisiológicas

Ricobendazole is a key metabolite of albendazole and acts as an anthelmintic. It has been shown to induce apoptosis in human cancer cell line HT-29, possibly by arresting cell cycle at the G₂/M phase.

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Informações de segurança

• Pictogramas: GHS08,GHS07,GHS09
• Palavra indicadora: Warning
• Frases de perigo: H317,H361d,H373,H410
• Declarações de precaução: P202 - P260 - P273 - P280 - P302 + P352 - P308 + P313
• Classificações de perigo: Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1 - STOT RE 2 Oral
• Órgãos-alvo: Adrenal gland,spleen,male reproductive organs,Blood
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable