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Key Documents

PHR1777

Supelco

Orphenadrine Citrate

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Orphenadrine citrate salt, β-Dimethylaminoethyl 2-methylbenzhydryl ether citrate salt, o-Methyldiphenhydramine citrate salt

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About This Item

Fórmula empírica (Notação de Hill):
C18H23NO · C6H8O7
Número CAS:
Peso molecular:
461.50
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to Ph. Eur. Y0000101
traceable to USP 1479009

família API

orphenadrine

Certificado de análise (CofA)

current certificate can be downloaded

embalagem

pkg of 1 g

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

OC(=O)CC(CC(O)=O)C(O)=O.CN(C)CCOC(c1ccccc1)c2ccccc2C

InChI

1S/C18H23NO.C6H8O6/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;7-4(8)1-3(6(11)12)2-5(9)10/h4-12,18H,13-14H2,1-3H3;3H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

chave InChI

XLSFUJUURNFSCL-UHFFFAOYSA-N

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Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Orphenadrine Citrate is an analog of diphenhydramine antihistamine drug. It operates as a centrally acting skeletal muscle relaxant and effectively serves to relieve painful skeletal muscle spasms by working as an analgesics.

Aplicação

Orphenadrine Citrate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography as well as spectrophotometry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Ações bioquímicas/fisiológicas

Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA8433 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Skull and crossbones

Palavra indicadora

Danger

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Visite a Biblioteca de Documentos

Development of a capillary electrophoresis method for the determination of orphenadrine citrate in tablets in the presence of paracetamol.
Haj-Ali DN and Hamdan II
Saudi Pharmaceutical Journal : SPJ : The Official Publication of the Saudi Pharmaceutical Society, 18(4), 233-237 (2010)
Spectrophotometric determination of phenylephrine HCl and orphenadrine citrate in pure and in dosage forms.
Shama SA
Journal of Pharmaceutical and Biomedical Analysis, 30(4), 1385-1392 (2002)
Khaled Darwish et al.
Chemical & pharmaceutical bulletin, 60(11), 1426-1436 (2012-11-06)
New, simple, rapid and precise reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of orphenadrine citrate, caffeine and aspirin in presence of aspirin degradation products, orphenadrine citrate and caffeine process related impurities, and excipients. Good resolution and

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