PHR1450

Capsaicin

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): Capsaicin, 8-Methyl-N-vanillyl-trans-6-nonenamide
• Fórmula linear: (CH₃)₂CHCH=CH(CH₂)₄CONHCH₂C₆H₃-4-(OH)-3-(OCH₃)
• Número CAS: 404-86-4
• Peso molecular: 305.41
• Beilstein: 2816484
• Número CE: 206-969-8
• Número MDL: MFCD00017259
• Código UNSPSC: 41116107
• ID de substância PubChem: 329822610
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to Ph. Eur. Y0000671; traceable to USP 1091108
• família API: capsaicin
• Certificado de análise (CofA): current certificate can be downloaded
• embalagem: pkg of 1 g
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• pf: 62-65 °C (lit.)
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O
• InChI: 1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
• chave InChI: YKPUWZUDDOIDPM-SOFGYWHQSA-N
• Informações sobre genes: human ... TRPV1(7442)

Descrição

Descrição geral

Capsaicin is an alkaloid occurring naturally in pepper plants related to Capsicum annuum. It is the major ingredient responsible for the hot pungent taste in chillies.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Ações bioquímicas/fisiológicas

Prototype vanilloid receptor agonist. Neurotoxin; activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect; systemic administration can be neurotoxic to capsaicin-sensitive cells, especially in newborn animals. Active component of chili peppers.

Prototype vanilloid receptor agonist; neurotoxin. Active component of chili peppers.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA2843 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informações de segurança

• Pictogramas: GHS06,GHS08,GHS05
• Palavra indicadora: Danger
• Frases de perigo: H300,H315,H317,H318,H334,H335
• Declarações de precaução: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 2 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 235.4 °F - closed cup
• Ponto de fulgor (°C): 113 °C - closed cup