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Documentos

P1650000

Pilocarpina

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

(3S,4R)-4,5-Di-hidro-3-etil-4-(1-metil-1H-imidazol-5-il-metil)-2(3H)-furanona

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About This Item

Fórmula empírica (Notação de Hill):
C11H16N2O2 · HCl
Número CAS:
54-71-7
Peso molecular:
244.72
Beilstein:
4034491
Número MDL:
MFCD00012722
Código UNSPSC:
41116107
ID de substância PubChem:
329820102
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

pilocarpine

fabricante/nome comercial

EDQM

pf

202-205 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

cadeia de caracteres SMILES

Cl.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1

chave InChI

RNAICSBVACLLGM-GNAZCLTHSA-N

Informações sobre genes

human ... CHRM1(1128) , CHRM3(1131)

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Pilocarpine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

Agonista não seletivo do receptor muscarínico de acetilcolina; usado para produzir um modelo experimental de epilepsia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H300 + H330

Declarações de precaução

P301 + P310 + P330 - P304 + P340 + P310

Classificações de perigo

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

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Certificados de análise (COA)

Lot/Batch Number

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Maxime Lévesque et al.
Seizure, 25, 18-25 (2015-02-04)
Mesial temporal lobe epilepsy (MTLE) is the most prevalent type of partial epileptic disorders. In this study, we have analyzed the impact of levetiracetam (LEV) in the pilocarpine model of MTLE. Sprague-Dawley rats (n=19) were injected with pilocarpine (380 mg/kg
Olav B Smeland et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(7), 1090-1097 (2013-04-25)
Although certain metabolic characteristics such as interictal glucose hypometabolism are well established for temporal lobe epilepsy (TLE), its pathogenesis still remains unclear. Here, we performed a comprehensive study of brain metabolism in a mouse model of TLE, induced by pilocarpine-status
Rashmi M Risbud et al.
PloS one, 8(1), e53464-e53464 (2013-01-12)
MicroRNAs regulate protein synthesis by binding non-translated regions of mRNAs and suppressing translation and/or increasing mRNA degradation. MicroRNAs play an important role in the nervous system including controlling synaptic plasticity. Their expression is altered in disease states including stroke, head
Georgette L Suidan et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(9), 2112-2120 (2013-07-05)
Aberrant blood-brain barrier (BBB) permeability is a hallmark pathology of many central nervous system diseases. von Willebrand factor (VWF) is stored in endothelial Weibel-Palade bodies from where it is released on activation into plasma and basement membrane. The role of
Linda Holtman et al.
Epilepsia, 54(4), 589-595 (2013-02-13)
Brain inflammation occurs during epileptogenesis and may contribute to the development and progression of temporal lobe epilepsy. Recently, several studies have indicated that seizures may also increase specific blood plasma cytokine levels in animal models as well as in human
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