N5410

Nicotinic acid

meets USP testing specifications

• Sinônimo(s): 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B₃
• Fórmula empírica (Notação de Hill): C₆H₅NO₂
• Número CAS: 59-67-6
• Peso molecular: 123.11
• Beilstein: 109591
• Número CE: 200-441-0
• Número MDL: MFCD00006391
• Código UNSPSC: 12352106
• ID de substância PubChem: 24897734
• NACRES: NA.21

Propriedades

• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• Agency: USP/NF; meets USP testing specifications
• Ensaio: 99.0-101.0% dry basis
• Formulário: powder
• cor: white
• pf: 236-239 °C (lit.)
• aplicação(ões): pharmaceutical (small molecule)
• cadeia de caracteres SMILES: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• chave InChI: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• Informações sobre genes: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

Descrição

Descrição geral

Nicotinic acid, also referred to as niacin or as vitamin B₃, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.

Aplicação

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.

Ações bioquímicas/fisiológicas

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H319
• Declarações de precaução: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classificações de perigo: Eye Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 379.4 °F - closed cup
• Ponto de fulgor (°C): 193 °C - closed cup
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves