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Documentos Principais

B1000000

Betamethasone

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone

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About This Item

Fórmula empírica (Notação de Hill):
C22H29FO5
Número CAS:
Peso molecular:
392.46
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

fonte biológica

synthetic

grau

pharmaceutical primary standard

Agency

EP

família API

betamethasone

embalagem

pkg of 60 mg

fabricante/nome comercial

EDQM

condição de armazenamento

protect from light

cor

white

pf

235-237 °C (lit.)
235.6 °C (456.1°F at 1013.0 hPa)

solubilidade

water: slightly soluble 0.063 g/L at 37 °C

densidade

0.305 g/cm3 at 25 °C (77°F)

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

Condições de expedição

ambient

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

chave InChI

UREBDLICKHMUKA-DVTGEIKXSA-N

Informações sobre genes

human ... NR3C1(2908)

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Descrição geral

Betamethasone, a synthetic glucocorticoid, belongs to the corticosteroid family of active pharmaceutical ingredients (APIs).

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Betamethasone EP reference standard may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

produto relacionado

Nº do produto
Descrição
Preços

Pictogramas

Health hazard

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Repr. 1B - STOT RE 2

Órgãos-alvo

Liver,Kidney,Endocrine system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Betamethasone
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 67(3), 4918-4920 (2021)
Simultaneous determination of dexamethasone and betamethasone in pharmaceuticals by reversed-phase HPLC
Santos-Montes A, et al.
Chromatographia, 39(9-10), 539-542 (1994)
Hanna Norberg et al.
The Journal of pediatrics, 163(3), 711-716 (2013-05-09)
To determine the relationship between repeat courses of antenatal corticosteroids (ACS) and risk factors for cardiovascular disease in adolescents and young adults. We assessed body mass index, blood pressure, arterial stiffness, blood lipids, and insulin resistance (IR) in a Swedish
Jennifer J P Collins et al.
American journal of physiology. Lung cellular and molecular physiology, 304(6), L438-L444 (2013-01-22)
Inflammation and antenatal glucocorticoids, the latter given to mothers at risk for preterm birth, affect lung development and may contribute to the development of bronchopulmonary dysplasia (BPD). The effects of the combined exposures on inflammation and antenatal glucocorticoids on transforming
Ran D Goldman
Canadian family physician Medecin de famille canadien, 59(1), 37-38 (2013-01-24)
Should I prescribe estrogen cream to treat labial adhesion in my prepubertal female patients? Many physicians offer young girls estrogen cream to be applied on the labia for several weeks to treat labial adhesion. While no randomized controlled trial data

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