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A0325450

Alfacalcidol

Name: Alfacalcidol
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

1α-Hydroxyvitamin D₃, 1α-Hydroxycholecalciferol, Alfacalcidol

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About This Item

Fórmula empírica (Notação de Hill):

C₂₇H₄₄O₂

Número CAS:

41294-56-8

Peso molecular:

400.64

Número MDL:

MFCD00868328

Código UNSPSC:

41116107

ID de substância PubChem:

329770599

NACRES:

NA.24

fonte biológica

synthetic

grau

pharmaceutical primary standard

Agency

família API

alfacalcidol

forma

solid

fabricante/nome comercial

EDQM

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C

InChI

1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1

chave InChI

OFHCOWSQAMBJIW-AVJTYSNKSA-N

Informações sobre genes

human ... VDR(7421)

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing pharmacopoeia.

Alfacalcidol is an active metabolite of vitamin D, used as a vitamin supplement due to it longer half-life. It is found to be effective in regulating calcium balance/bone metabolism.

Aplicação

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

Synthetic vitamin D₃ analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Pictogramas

GHS06

Palavra indicadora

Danger

Frases de perigo

H300

Declarações de precaução

P264 - P270 - P301 + P310 - P405 - P501

Classificações de perigo

Acute Tox. 1 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Novel approach for the determination of alfacalcidol in bulk and tablet dosage form using spectrophotometric method

Saeed-Ul-Hassan S, et al.

Latin American Journal of Pharmacy, 32(5), 784-788 (2013)

Randomized controlled trial of alfacalcidol supplementation for the reduction of hypocalcemia after total thyroidectomy.

Laurent Genser et al.

American journal of surgery, 207(1), 39-45 (2013-10-15)

The aim of this study was to evaluate the effect of perioperative alfacalcidol on postoperative hypocalcemia after total thyroidectomy. A total of 219 patients scheduled for total thyroidectomy were randomized into groups not receiving (group A) or receiving (group B)

Metabolic stability of 3-epi-1α,25-dihydroxyvitamin D3 over 1 α 25-dihydroxyvitamin D3: metabolism and molecular docking studies using rat CYP24A1.

Steve Y Rhieu et al.

Journal of cellular biochemistry, 114(10), 2293-2305 (2013-04-23)

3-epi-1α,25-dihydroxyvitamin D3 (3-epi-1α,25(OH)2D3), a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion. These VDR-mediated actions of 3-epi-1α,25(OH)2D3 needed an explanation as 3-epi-1α,25(OH)2D3, unlike

The use of alfacalcidol in the prevention of bone disease in early renal failure.

J A Kanis

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 10 Suppl 4, 23-28 (1995-01-01)

Eldecalcitol improves mechanical strength of cortical bones by stimulating the periosteal bone formation in the senescence-accelerated SAM/P6 mice - a comparison with alfacalcidol.

Ayako Shiraishi et al.

The Journal of steroid biochemistry and molecular biology, 144 Pt A, 119-123 (2013-11-06)

Eldecalcitol (ELD), a 2β-hydroxypropyloxy derivative of 1α,25(OH)2D3, is a potent inhibitor of bone resorption that has demonstrated a greater effect at reducing the risk of fracture in osteoporotic patients than alfacalcidol (ALF). In the present study, we used the senescence-accelerated

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