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Documentos Principais

A0325200

Alcuronium chloride

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

N,N′-Diallylnortoxiferinium dichloride

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About This Item

Fórmula empírica (Notação de Hill):
C44H50Cl2N4O2
Número CAS:
Peso molecular:
737.80
Número MDL:
Código UNSPSC:
41116107
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

alcuronium

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[Cl-].[Cl-].[N+]21([C@@H]3C4([C@H]5N(c%11c4cccc%11)\C=C6/[C@@H]7N(c8c(cccc8)C97[C@H]%10[N+](CC9)(C\C(=C\CO)\C/6C%10)CC=C)\C=C/5\C(C3)\C(=C/CO)\C2)CC1)CC=C

InChI

1S/C44H50N4O2.2ClH/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49;;/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2;2*1H/q+2;;/p-2/b29-13-,30-14-,33-25-,34-26-;;/t31?,32?,39-,40-,41-,42-,43?,44?,47?,48?;;/m0../s1

chave InChI

CPYGBGOXCJJJGC-ZHNYPADJSA-L

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Alcuronium chloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Pictogramas

Skull and crossbones

Palavra indicadora

Danger

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 2 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Anaphylactic shock to neuromuscular blocking agent: a familial history.
P Duvaldestin et al.
Anesthesiology, 90(4), 1211-1212 (1999-04-14)
Lauren T May et al.
The Journal of pharmacology and experimental therapeutics, 312(1), 382-390 (2004-08-31)
The effects of prolonged exposure of M(2) muscarinic acetylcholine receptors (mAChRs), stably expressed in Chinese hamster ovary cells, to the allosteric modulators gallamine, alcuronium, and heptane-1,7-bis (dimethyl-3'-phthalimidopropyl)-ammonium bromide (C(7)/3'-phth) were compared with the effects of the agonist carbachol (CCh) and
A Lanzafame et al.
The Journal of pharmacology and experimental therapeutics, 282(1), 278-285 (1997-07-01)
Functional studies were conducted on guinea pig atrial muscarinic acetylcholine M2 receptors with the allosteric modulators heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)ammonium bromide (C7/3'-phth), gallamine and alcuronium to determine whether these ligands are able to recognize a common accessory site. The three modulators inhibited the
C Tränkle et al.
The Journal of pharmacology and experimental therapeutics, 279(2), 926-933 (1996-11-01)
Various compounds are known to allosterically modulate the binding of ligands to muscarinic receptors. Most of these compounds have another predominant pharmacological action. Identification of the potent representatives should be useful for the development of allosteric modulators that are specific
A Krejcí et al.
Molecular pharmacology, 60(4), 761-767 (2001-09-20)
To clarify the involvement of specific domains of muscarinic receptors in the action of allosteric modulators, muscarinic M(3) receptors (on which allosteric interactions are weak) were genetically modified to become more similar to M(2) receptors (on which allosteric interactions are

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