MABS1284-B

Anti-Apolipoprotein(a) Antibody, clone LPA4 Antibody, Biotin Conjugate

clone LPA4, from mouse, biotin conjugate

• Sinônimo(s): Apo(a), Lp(a)
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• conjugado: biotin conjugate
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: LPA4, monoclonal
• reatividade de espécies: human, nonhuman primates
• técnica(s): ELISA: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• Isotipo: IgG1κ
• nº de adesão UniProt: P08519
• Condições de expedição: ambient
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... APOA1(335)

Descrição

Descrição geral

Apolipoprotein(a) (UniProt P08519; also known as Apo(a), Lp(a)) is encoded by the LPA gene (Gene ID 4018) in human. Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It is synthesized with a signal peptide (aa 1-19) that is subsequently cleaved off. Lipoprotein (a)/Lp(a) is composed of Apo(a) covalently bound to apolipoprotein B-100/ApoB via a single disulfide bond on kringle (K)IV type 9 (KIV9) to a site near ApoB low density lipoprotein (LDL) receptor-binding site. Structurally, Apo (a) contains ten subtypes of KIV sequences, with the KIV2 subtype present in multiple identical repeats, followed by a KV sequence and an inactive protease domain. Elevated levels of Lp(a) are considered as a risk factor in the development of cardiovascular diseases and peripheral arterial disease. Lp(a) is a preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and circulating levels of oxidized LDL are strongly associated with angiographically documented coronary artery disease. Apo(a) is known to be proteolytically cleaved. Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis.

Especificidade

Clone LPA4 detects Apolipoprotein(a) in human and non-human primates.

Imunogênio

Human Lipoprotein a (Lp(a)).

Aplicação

Anti-Apolipoprotein(a), clone LPA4, Biotin Conjugate, Cat. No. MABS1284-B, is a mouse monoclonal antibody that detects Apolipoprotein (a)/Apo(a)/Lp(a) in human and non-human primates and has been tested for use in ELISA, Immunoprecipitation, and Western Blotting.

ELISA Analysis: A representative lot detected Apolipoprotein(a) in ELISA applications (Pedersen, T.X., et. al. (2010). J Lipid Res. 51(10):2967-75; Leibundgut, G., et. al. (2013). J Lipid Res. 54(10):2815-30).

ELISA Analysis: 0.1 µg/mL from a representative lot detected Apolipoprotein(a) in Patient Lp(a) Plasma sample (Courtesy of Dr. Sotirios Tsimikas, M.D., University of California at San Diego, USA).

Immunoprecipitation Analysis: A representative lot detected Apolipoprotein(a) in Immunoprecipitation applications (Tsimikas, S., et. al. (2004). Circulation. 109(25):3164-70).

Western Blotting Analysis: A representative lot detected Apolipoprotein(a) in Western Blotting applications (Leibundgut, G., et. al. (2013). J Lipid Res. 54(10):2815-30).

Research Category
Signaling

Qualidade

N/A

Descrição-alvo

501.32 kDa calculated for Apolipoprotein A

forma física

Protein G purified

Purified mouse monoclonal antibody IgG1 in PBS with 1.5% BSA and 0.1% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Outras notas

Concentration: Please refer to lot specific datasheet.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): does not flash
• Ponto de fulgor (°C): does not flash