MABN263

Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8

clone 10F10-C1-B8, from mouse

• Sinônimo(s): Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• clone: 10F10-C1-B8, monoclonal
• application: ICC; WB
• reatividade de espécies: rat
• técnica(s): immunocytochemistry: suitable; western blot: suitable
• citations: 1

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 10F10-C1-B8, monoclonal
• reatividade de espécies: rat
• técnica(s): immunocytochemistry: suitable; western blot: suitable
• Isotipo: IgG2bκ
• nº de adesão NCBI: NP_899156
• nº de adesão UniProt: P18508
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: rat ... Gabrg2(29709)

Descrição

Descrição geral

GABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A). GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e. α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain. GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine. The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.

Imunogênio

Linear peptide corresponding to rat GABA(A) receptor subunit gamma-2.

Aplicação

Detect GABA(A) receptor subunit gamma-2 using this Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8 validated for use in Western Blotting, ICC.

Immunocytochemistry Analysis: A 1:250 dilution from a representative lot detected GABA(A) receptor subunit gamma-2 in rat hippocampal neurons. Image courtesy from the laboratory of Dr. Jaideep Kapur, University of Virginia.

Qualidade

Evaluated by Western Blot in PC-12 cell lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected GABA(A) receptor subunit gamma-2 in 10 µg of PC-12 cell lysate.

Descrição-alvo

~54 kDa observed

forma física

Format: Purified

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable